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MOTIVATION RNA-seq is replacing microarrays as the primary tool for gene expression studies. Many RNA-seq studies have used insufficient biological replicates, resulting in low statistical power and inefficient use of sequencing resources. RESULTS We show the explicit trade-off between more biological replicates and deeper sequencing in increasing power(More)
In breast cancer, nuclear receptors (NRs) play a prominent role in governing gene expression, have prognostic utility, and are therapeutic targets. We built a regulatory map for 24 NRs, six chromatin state markers, and 14 breast-cancer-associated transcription factors (TFs) that are expressed in the breast cancer cell line MCF-7. The resulting network(More)
This paper examines how transformational leadership (TFL) climate influences employees’ team identity and their intentions to share knowledge and how team knowledge sharing intention subsequently influences team innovativeness. Data was collected from 301 employees comprising 52 R&D teams. Hypotheses were tested with both hierarchical linear modeling (HLM)(More)
Most cancer risk-associated single nucleotide polymorphisms (SNPs) identified by genome-wide association studies (GWAS) are noncoding and it is challenging to assess their functional impacts. To systematically identify the SNPs that affect gene expression by modulating activities of distal regulatory elements, we adapt the self-transcribing active(More)
46 47 Analyzing de novo mutations (DNMs) in protein-coding genes from whole-exome sequencing 48 (WES) data has emerged as a powerful tool for mapping risk genes of autism spectrum disorder 49 (ASD). The impact of non-coding mutations in ASD, however, has been largely unknown. This 50 represents a large gap in our understanding of the genetics of ASD, as the(More)
Genome-wide quantification of enhancer activity in the human genome has proven to be a challenging problem. Recent efforts have led to the development of powerful tools for enhancer quantification. However, because of genome size and complexity, these tools have yet to be applied to the whole human genome.  In the current study, we use a human prostate(More)
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