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The cerebellum has been implicated as a major player in producing temporal acuity. Theories of cerebellar timing typically emphasize the role of the cerebellar cortex while overlooking the role of the deep cerebellar nuclei (DCN) that provide the sole output of the cerebellum. Here we review anatomical and electrophysiological studies to shed light on the… (More)
A 70-year-old man was treated with oral mexiletene because of ventricular premature beats due to ischemic heart disease. He developed a severe maculopapular rash which did not respond to antiallergic treatment, but disappeared after discontinuation of the drug. Adverse effects on the central nervous, cardiovascular and gastrointestinal systems have been… (More)
(Bagnall et al., 2009). There are no reliable classifi cations of single cells into subgroups based solely on morphological features due to a considerable overlap in some of their features. For example, the soma size of the excitatory projection neurons ranges from 15 to 35 microns while that of the inhibitory ones ranges from 5 to 20 microns. The DCN… (More)
The authors present a typical case of Holt-Oram syndrome in an eighty-year-old woman. The patient had atrial-septal defect and phocomelia but was independent in the activities of daily living.