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This paper proposes a new method for computing page importance, referred to as BrowseRank. The conventional approach to compute page importance is to exploit the link graph of the web and to build a model based on that graph. For instance, PageRank is such an algorithm, which employs a discrete-time Markov process as the model. Unfortunately, the link graph(More)
Circadian rhythm is fundamental in regulating a wide range of cellular, metabolic, physiological, and behavioral activities in mammals. Although a small number of key circadian genes have been identified through extensive molecular and genetic studies in the past, the existence of other key circadian genes and how they drive the genomewide circadian(More)
OBJECTIVE Rolipram, a 3'-5'-cyclic adenosine monophosphate (cAMP)-dependent phosphodiesterase 4 (PDE4) inhibitor, has long been studied for its immune modulating effects in the treatment of experimental autoimmune encephalomyelitis (EAE). In the current study, we investigated the effects of rolipram on remyelination after cuprizone- or lysolecithin-induced(More)
The body temperature is considered a universal cue by which the master clock synchronizes the peripheral clocks in mammals, but the mechanism is not fully understood. Here we identified two cold-induced RNA-binding proteins (RBPs), Cirbp and Rbm3, as important regulators for the temperature entrained circadian gene expression. The depletion of Cirbp or Rbm3(More)
Sleep is an animal behavior shared by a wide range of species, suggesting that it must serve fundamental functions. However, the functions and molecular mechanisms underlying sleep are largely unknown. Through a meta-analysis of all available short-term sleep deprivation (SD) microarray data in mouse brain, we identified 91 key mouse SD-affected genes and(More)
This paper is concerned with a framework to compute the importance of webpages by using real browsing behaviors of Web users. In contrast, many previous approaches like PageRank compute page importance through the use of the hyperlink graph of the Web. Recently, people have realized that the hyperlink graph is incomplete and inaccurate as a data source for(More)
This paper is concerned with Markov processes for computing page importance. Page importance is a key factor in Web search. Many algorithms such as PageRank and its variations have been proposed for computing the quantity in different scenarios, using different data sources, and with different assumptions. Then a question arises, as to whether these(More)