Yutaka Yoshii

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Cigarette smoke (CS)-induced cellular senescence has been implicated in the pathogenesis of chronic obstructive pulmonary disease, and SIRT6, a histone deacetylase, antagonizes this senescence, presumably through the attenuation of insulin-like growth factor (IGF)-Akt signaling. Autophagy controls cellular senescence by eliminating damaged cellular(More)
  • Zenya Saito, Yugo Kaneko, Akira Kinoshita, Yusuke Kurita, Kyuto Odashima, Tsugumi Horikiri +5 others
  • 2016
BACKGROUND The effectiveness of hepatoprotective drugs for DIH (drug induced hepatotoxicity) during tuberculosis treatment is not clear. We evaluated the effectiveness of hepatoprotective drugs by comparing the period until the normalization of hepatic enzymes between patients who were prescribed with the hepatoprotective drugs after DIH was occurred and(More)
Respiratory infection is a major cause of exacerbation in chronic obstructive pulmonary disease (COPD). Infectious contributions to exacerbations remain incompletely described. We therefore analyzed respiratory tract samples by comprehensive real-time polymerase chain reaction (PCR) in combination with conventional methods. We evaluated multiple risk(More)
ditionally integrated are a newly designed voltage doubler-negative voltage generator (VDNVG) and a control logic circuit to control transmit and receive functions. The chip is capable of delivering 21-dBm output power at 39% efficiency with 2-V single power supply in transmit mode. By utilizing up-voltage and negative voltages generated from the generator,(More)
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