Yutaka Machida

Nobutaka Hattori3
Hiroto Eguchi2
Hideto Miwa2
Satoko Sekimoto-Tsuboi1
3Nobutaka Hattori
2Hiroto Eguchi
2Hideto Miwa
1Satoko Sekimoto-Tsuboi
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INTRODUCTION Hypothyroidism is one of the most important causes of treatable dementia, and psychosis occasionally associated with it is known as myxedema madness. We report a case of a 90-year-old patient who developed myxedema madness acutely without overt clinical symptoms and signs suggestive of hypothyroidism. CASE PRESENTATION A 90-year-old Japanese(More)
BACKGROUND Immunodeficiency with a thymoma (Good's syndrome) is a rare condition occurring in patients with adult-onset hypogammaglobulinemia that is progressive after the removal of thymoma. Recently, we encountered a patient with Good's syndrome who suddenly developed opportunistic encephalitis 4 years after the resection of thymoma without a history of(More)
Parkin, a product of the gene responsible for autosomal recessive juvenile parkinsonism (AR-JP), is an important player in the pathogenic process of Parkinson's disease (PD). Despite numerous studies including search for the substrate of parkin as an E3 ubiquitin-protein ligase, the mechanism by which loss-of-function of parkin induces selective(More)
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