Yutaka Kono

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This study investigated the mechanism by which verapamil, which blocks 10R1, l-type Ca2+ channel and the HERG channel, blocks ATP-sensitive K+ (K(ATP)) channels. In whole cell patch experiments, verapamil reversibly inhibited cardiac type K(ATP) (Kir6.2/SUR2A) channels previously activated by 100-micromol/L pinacidil. In inside-out patch experiments,(More)
Two novel classes of diphenyloxazole and Ndelta-Z-ornithine derivatives as highly potent and selective EP(4) antagonists have been discovered. The optimized diphenyloxzole 8 and Ndelta-Z-ornithine 11 effectively competed with [(3)H]PGE(2) binding to human recombinant EP(4), with K(i) values of 0.30 nM and 0.91 nM, respectively, and were selective for all(More)
This paper presents a scalable FPGA/ASIC implementation architecture for high-speed parallel table-lookup-coding using multiported content addressable memory, aiming at facilitating effective tablelookup-coding solutions. The multi-ported CAM adopts a Flexible Multiported Content Addressable Memory (FMCAM) technology, which represents an effective parallel(More)
1. Introduction Multimedia applications, requiring the capabilities of codec processing, image processing or image recognition, have spread to the end-user environment. In particular, the modern communication network infrastructure accelerates the development of on-demand systems, digital broadcasting, mobile machinery and so on. Furthermore, security(More)
Rifampicin (RFP) is a semisynthetic antibiotic derived from the rifamycins and is one of the most commonly used pharmaceutical compounds worldwide in the treatment of tuberculosis. We previously reported that low-dose and long-term oral administration of RFP to 6 hepatitis C virus-related liver cirrhosis patients who were at high risk for presenting with(More)
Arteriovenous fistula has superior patency over other accesses, but vascular access intervention therapy (VAIVT) for stenosis or thrombosis still remain major reasons for hospital admission of dialysis patients. The aim of this study was to examine the usefulness of systematic evaluation of vascular access by color-Doppler ultrasound (CDUS). This study was(More)
Sarcolemmal adenosine 5′-triphosphate-sensitive K+ channels (KATP) are dramatically up-regulated by a membrane phospholipid, phosphatidyl-inositol-4,5-bisphosphate (PIP2). During ischaemia, L-palmitoylcarnitine (L-PC), a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment. We therefore investigated whether(More)
Angiogenesis is an important therapeutic target in cancer, and to fully exploit its therapeutic potential, combination chemotherapeutic/antiangiogenic regimens should be optimized and delivered earlier to more patients. Ideally, this could be done by a single potent oral agent with established safety. Rifampicin, a semisynthetic antibiotic derived from the(More)
It is objective and practical for an electric machinery and apparatus test to computerize its diagnosis process with fault location identification. It is possible to recognize a fault location from measured voltage and current information by using a Kohonen's self-organizing map (SOM) which only needs a learning process of relation between the locations and(More)