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BACKGROUND & AIMS The existence of a direct pathogenic link between hepatitis C virus (HCV) infection and myocardial injury has not been confirmed. We investigated the association between myocardial conditions and HCV in patients with HCV-related chronic hepatitis using thallium-201 myocardial scintigraphy. METHODS In 217 consecutive cases of chronic HCV(More)
We investigated the molecular defect of the ferrochelatase gene in a Japanese patient with erythropoietic protoporphyria (EPP), and identified a novel 16 base pair (574-589) deletion within exon 5. This deletion resulted in a frame-shift mutation and created a premature stop codon at amino acid position 198. The same molecular defect was also identified in(More)
Currently available tumor markers for hepatocellular carcinoma (HCC) are alpha-fetoprotein (AFP), lens culinaris agglutinin-reactive AFP (AFP-L3), and Des-gamma-carboxy prothrombin (DCP). However, their positive rate can not surpass abdominal ultrasonography (US) as modalities to detect small HCC at early stage, resulting in a possible delay of its(More)
BACKGROUNDS We previously reported a highly sensitive method for serum human telomerase reverse transcriptase (hTERT) mRNA for hepatocellular carcinoma (HCC). alpha-fetoprotein (AFP) and des-gamma-carboxy prothrombin (DCP) are good markers for HCC. In this study, we verified the significance of hTERTmRNA in a large scale multi-centered trial, collating(More)
A method estimating motion and planar surface parameters based on pixel intensity is proposed. Conventional approaches for estimation of these parameters are based on detected edge or feature points correspondence. Thus the problem is one of searching for any point which corresponds to feature points in other images. These approaches provide a solution from(More)
BACKGROUND/AIMS Moderate polyclonal hypergammaglobulinemia is a common finding in chronic viral liver disease; however, its clinical significance has not been completely elucidated. We attempted to determine whether serum immunoglobulin levels were correlated with the disease severity and the treatment outcome in patients with chronic hepatitis C. (More)
deficiencies in ALAD porphyria-aminolevulinate dehydratase (ALAD) δ Highly heterogeneous nature of Updated information and services can be found at: (1174 articles) Red Cells (3667 articles) Clinical Trials and Observations Articles on similar topics can be found in the following Blood collections The properties of 9 ␦-aminolevulinate de-hydratase (ALAD)(More)
We report a 36-year-old woman presenting with hypertensive encephalopathy followed by bulbar palsy and quadriplegia. After an extensive screening for secondary causes of hypertension, the patient was suspected of having pheochromocytoma due to increased levels of catecholamines in the plasma and the urine, and positive (131)I-metaiodobenzylguanidine (MIBG)(More)
Two cases of hepatocellular carcinoma metastatic to the oral cavity are presented. One patient had metastases to the maxilla and finally, to the mandible, and the other patient, to the mandible. Both cases histologically showed highly-differentiated trabecular hepatocellular carcinoma which had vascularized stroma, explaining the frequently observed oral(More)
O n the basis of clinical results in 159 cases of ulcerative colitis encountered at the T h i r d Depar t men t of In t e rna l Medicine, Tohoku Univers i ty Hospital, dur ing the 22 year period from 1954 to 1975, various clinical aspects such as its incidence, laboratory findings, complications, t r e a t m e n t and prognosis have been investigated. T he(More)