Yutaka Hasegawa

Junta Imai4
Keizo Kaneko4
Kenji Uno4
4Junta Imai
4Keizo Kaneko
4Kenji Uno
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  • Toshinobu Suzuki, Junta Imai, Tetsuya Yamada, Yasushi Ishigaki, Keizo Kaneko, Kenji Uno +4 others
  • 2011
1 OBJECTIVE—Interleukin-6 (IL-6) has a significant impact on glucose metabolism. However, the effects of IL-6 on insulin secretion from pancreatic b-cells are controversial. Therefore, we analyzed IL-6 effects on pancreatic b-cell functions both in vivo and in vitro. RESEARCH DESIGN AND METHODS—First, to examine the effects of IL-6 on in vivo insulin(More)
Metabolism is coordinated among tissues and organs via neuronal signals. Levels of circulating amino acids (AAs), which are elevated in obesity, activate the intracellular target of rapamycin complex-1 (mTORC1)/S6kinase (S6K) pathway in the liver. Here we demonstrate that hepatic AA/mTORC1/S6K signalling modulates systemic lipid metabolism via a mechanism(More)
BACKGROUND Glutamic acid decarboxylase (GAD) is the rate-limiting enzyme in the synthesis of γ-aminobutyric acid (GABA). Anti-GAD antibodies (GADA) are associated with the progression of stiff person syndrome and other neurological diseases, as well as the immune-mediated (type 1) diabetes. GABA is one of the most widely distributed neurotransmitters, but(More)
AIMS/INTRODUCTION We investigated impacts of the Great East Japan Earthquake on diabetic patients and characterized those with disaster-susceptible diabetes. MATERIALS AND METHODS We enrolled 497 diabetic patients who had been followed at hospitals in devastated areas. We collected metabolic parameters prospectively, 1 and 3 months after the earthquake,(More)
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