Yuta Katayama

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TRIM8 is a member of the protein family defined by the presence of a common domain structure composed of a tripartite motif: a RING-finger, one or two B-box domains and a coiled-coil motif. Here, we show that TRIM8 interacts with protein inhibitor of activated STAT3 (PIAS3), which inhibits IL-6-dependent activation of STAT3. Ectopic expression of TRIM8(More)
Autism spectrum disorder (ASD) comprises a range of neurodevelopmental disorders characterized by deficits in social interaction and communication as well as by restricted and repetitive behaviours. ASD has a strong genetic component with high heritability. Exome sequencing analysis has recently identified many de novo mutations in a variety of genes in(More)
Invasive fungal rhinosinusitis is a life-threatening fungal infection with a reported incidence of around 2% in patients with haematological malignancies (DeShazo RD et al., New Engl J Med 1997; 337: 254–59). The prognosis of patients with invasive fungal rhinosinusitis varies depending on the underlying disease, the stage of infection and antifungal(More)
Although the brains of patients with schizophrenia and bipolar disorder exhibit decreased brain pH relative to those of healthy controls upon postmortem examination, it remains controversial whether this finding reflects a primary feature of the diseases or is a result of confounding factors such as medication and agonal state. To date, systematic(More)
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