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Active demethylation of paternal genome in mammalian zygotes.

• Hany M. Abdalla, Yusuke Yoshizawa, Shinichi Hochi
• The Journal of reproduction and development
• 2009

Epigenetic reprogramming in early preimplantation embryos, that refers to erasing and remodeling epigenetic marks such as DNA methylation, is essential for differentiation and development. In many… (More)

Impaired active demethylation of the paternal genome in pronuclear-stage rat zygotes produced by in vitro fertilization or intracytoplasmic sperm injection.

• Yusuke Yoshizawa, Megumi Kato, Masumi Hirabayashi, Shinichi Hochi
• Molecular reproduction and development
• 2010

This study was designed to investigate the effect of in vitro production systems of rat zygotes such as in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) on demethylation… (More)

Availability of subfertile transgenic rats expressing the c-myc gene as recipients for spermatogonial transplantation

• Masumi Hirabayashi, Yusuke Yoshizawa, Megumi Kato, Takashi Tsuchiya, Shizuko Nagao, Shinichi Hochi
• Transgenic Research
• 2008

The spermatogonial transplantation system was applied to evaluate stem cell kinetics and niche quality and to produce gene-modified animals using the stem cells after homologous recombination-based… (More)

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