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Role of Keap1-Nrf2 signaling in depression and dietary intake of glucoraphanin confers stress resilience in mice
The transcription factor Keap1-Nrf2 system plays a key role in inflammation which is involved in depression. We found lower expression of Keap1 and Nrf2 proteins in the prefrontal cortex (PFC), CA3… Expand
Dietary Intake of Sulforaphane-Rich Broccoli Sprout Extracts during Juvenile and Adolescence Can Prevent Phencyclidine-Induced Cognitive Deficits at Adulthood
Oxidative stress and inflammation play a role in cognitive impairment, which is a core symptom of schizophrenia. Furthermore, a hallmark of the pathophysiology of this disease is the dysfunction of… Expand
Sulforaphane accelerates acetaldehyde metabolism by inducing aldehyde dehydrogenases: relevance to ethanol intolerance.
AIMS Many East Asians are highly intolerant to even modest alcohol consumption. These individuals accumulate acetaldehyde, the primary metabolite of ethanol, because of a genetic polymorphism of… Expand
Glucoraphanin Ameliorates Obesity and Insulin Resistance Through Adipose Tissue Browning and Reduction of Metabolic Endotoxemia in Mice
Low-grade sustained inflammation links obesity to insulin resistance and nonalcoholic fatty liver disease (NAFLD). However, therapeutic approaches to improve systemic energy balance and chronic… Expand
Prophylactic effects of sulforaphane on depression-like behavior and dendritic changes in mice after inflammation.
Inflammation plays a role in the pathophysiology of depression. Sulforaphane (SFN), an isothiocyanate compound derived from broccoli, is a potent activator of the NF-E2-related factor-2 (Nrf2), which… Expand
Endothelium-dependent vasorelaxation effect of rutin-free tartary buckwheat extract in isolated rat thoracic aorta.
- Yusuke Ushida, T. Matsui, +5 authors Takami Kakuda
- Biology, Medicine
- The Journal of nutritional biochemistry
- 1 October 2008
The aim of this study was to point out the potential of tartary buckwheat on vascular functions. A nonabsorbed fraction of hot-water extract of tartary buckwheat on a SP70 column (TBSP-T), which was… Expand
Dietary glucoraphanin prevents the onset of psychosis in the adult offspring after maternal immune activation
- A. Matsuura, Tamaki Ishima, +11 authors K. Hashimoto
- Medicine, Biology
- Scientific Reports
- 1 February 2018
Maternal immune activation (MIA) contributes to behavioral abnormalities relevant to schizophrenia in adult offspring, although the molecular mechanisms underlying MIA-induced behavioral changes… Expand
Toll-like Receptors as a Target of Food-derived Anti-inflammatory Compounds*
- T. Shibata, F. Nakashima, +9 authors K. Uchida
- Medicine, Biology
- The Journal of Biological Chemistry
- 7 October 2014
Background: Vegetable-rich diets are associated with the reduced risk of inflammatory diseases. Results: Iberin, an isothiocyanate compound from cabbage, targeted TLRs, disrupted TLR dimerization,… Expand
Broccoli sprout extract induces detoxification-related gene expression and attenuates acute liver injury.
- K. Yoshida, Yusuke Ushida, +5 authors Yuji Nakai
- World journal of gastroenterology
- 21 September 2015
AIM To investigate the effects of broccoli sprout extract (BSEx) on liver gene expression and acute liver injury in the rat. METHODS First, the effects of BSEx on liver gene expression were… Expand
Dietary intake of glucoraphanin prevents the reduction of dopamine transporter in the mouse striatum after repeated administration of MPTP.
AIMS Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder. Although diet may influence the development of PD, the precise mechanisms underlying relationship between diet… Expand