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Site of drug absorption after oral administration: assessment of membrane permeability and luminal concentration of drugs in each segment of gastrointestinal tract.
This study was conducted to assess the site of drug absorption in the gastrointestinal (GI) tract after oral administration. Drug permeability to different regions of rat intestine, jejunum, ileumExpand
An enzymatic method for site-specific labeling of recombinant proteins with oligonucleotides.
DNA was site-specifically conjugated to a substrate peptide of microbial transglutaminase fused to the N- or C-terminus of target proteins without the loss of the proteins' functions of interest.
Fibroblastic foci, covered with alveolar epithelia exhibiting epithelial–mesenchymal transition, destroy alveolar septa by disrupting blood flow in idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease of unknown cause. IPF has a distinct histopathological pattern of usual interstitial pneumonia in whichExpand
Regional differences in the components of luminal water from rat gastrointestinal tract and comparison with other species.
PURPOSE The bile acids, phospholipids, inorganic ions, and pH in luminal fluid are very important factors for the dissolution and oral absorption of solid drugs. In this study, we evaluated theExpand
Inferring Latent Triggers of Purchases with Consideration of Social Effects and Media Advertisements
This paper proposes a method for inferring from single-source data the factors that trigger purchases, and find user segments according to the estimated factors. Expand
Combined effects of the drug distribution and mucus diffusion properties of self‐microemulsifying drug delivery systems on the oral absorption of fenofibrate
Graphical abstract Figure. No Caption available. &NA; We present the absorption improvement mechanism of fenofibrate (FFB), a Biopharmaceutics Classification System (BCS) class II drug, fromExpand
Estimating Latent People Flow without Tracking Individuals
Analyzing people flows is important for better navigation and location-based advertising. Expand
Nanoparticulation of poorly water soluble drugs using a wet-mill process and physicochemical properties of the nanopowders.
In order to improve the dissolution and oral absorption properties of poorly water soluble drugs such as omeprazole, albendazole and danazol, various dispersing agents were added to prepareExpand
Impact of Luminal Fluid Volume on the Drug Absorption After Oral Administration: Analysis Based on In Vivo Drug Concentration-Time Profile in the Gastrointestinal Tract.
The objective of this study is to clarify the influence of fluid volume in the gastrointestinal (GI) tract on the oral drug absorption. In vivo rat luminal concentrations of FITC-dextran (FD-4), aExpand
Functional immobilization of recombinant alkaline phosphatases bearing a glutamyl donor substrate peptide of microbial transglutaminase.
Covalent and site-specific protein immobilization catalyzed by microbial transglutaminase (MTG) was investigated using recombinant Escherichia coli alkaline phosphatase (AP) tagged with a glutamylExpand