Yusuke Shigematsu

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Renin plays a key role in controlling blood pressure through its specific cleavage of angiotensinogen to generate angiotensin I (AI). Although possible existence of the other angiotensin forming enzymes has been discussed to date, its in vivo function remains to be elucidated. To address the contribution of renin, we generated renin knockout mice.(More)
Receptive field size of rod-driven horizontal cells (HCs) in the carp retina was measured by the spread of responses to the slit of light stimulus with changing the distance from the recording electrode and it was found to decay with a single exponential function. By perfusing 10 microM dopamine (DA) the length constant of rod-driven HCs was reduced to half(More)
The response latency of horizontal cells in the carp retina was investigated by means of the stimulus-response crosscorrelation using a randomly modulated light of various wavelengths. R/G type cells produced two response components with some difference in latency; short-latency hyperpolarising response to green light and long-latency depolarising one to(More)
We previously identified various upstream and downstream regulatory elements and factors important for hepatic expression of the human angiotensinogen (ANG) gene, the precursor of vasoactive octapeptide angiotensin II. In the present study, to further investigate the molecular mechanism of human ANG transcriptional regulation, we generated transgenic mice(More)
A glass multimicroelectrode system for simultaneous intracellular recordings is described in which four pieces of micropipettes with rectangular cross section are arranged in a square compartment. Each tip position is shifted from the central axis of the electrode stem toward the crest line of its corner. Such micropipettes are mechanically bundled to one(More)