Yusuke Otsuka

Learn More
We trained rats to discriminate music by Bach from that by Stravinsky using operant conditioning. The rats successfully learned the discrimination and transferred their discrimination to novel music by the same artists. Then, we trained rats on concurrent-chain schedule in which the terminal links were associated with different music, Bach or Stravinsky.(More)
PURPOSE Ipilimumab (IPI), a monoclonal antibody against immune-checkpoint receptor cytotoxic T lymphocyte antigen-4, is designed to enhance antitumor T cell function. IPI 10 mg/kg plus dacarbazine (DTIC) significantly improved overall survival in a phase 3 study involving predominantly Caucasian patients, with an adverse event (AE) profile similar to that(More)
The purpose of this study was twofold: first, to create an index for a behavioral linkage analysis of serial sex crimes, and second, to construct a predictive model for the analysis. Data on 720 sex crimes (rape, indecent assault) committed by 360 offenders arrested between 1993 and 2005 throughout Japan were collected. The following seven behaviors were(More)
BACKGROUND The effects of olmesartan (OLM) on blood pressure and kidney function in Japanese patients with chronic kidney disease (CKD) were compared between 20 mg twice daily (BID) and 40 mg once daily (QD) treatments. METHODS The subjects were Japanese CKD patients with concurrent hypertension who had been treated with OLM 20 mg BID for at least 3(More)
Effects of hippocampal lesions on conditional discrimination were examined in rats. Rats were trained in a conditional drug discrimination paradigm using pentobarbital. They were able to learn the discrimination. After hippocampal lesions, all rats maintained discrimination. Thus a hippocampal lesion had no effect on retention of the conditional(More)
  • 1