• Publications
  • Influence
Synthesis and assignment of the absolute configuration of indenotryptoline bisindole alkaloid BE-54017.
Synthesis of the indenotryptoline bisindole alkaloid, BE-54017, was accomplished using osmium-promoted cis-dihydroxylation of maleimide as a key step. After optical resolution, the absoluteExpand
Visualization of long-term Mg2+ dynamics in apoptotic cells using a novel targetable fluorescent probe† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc03954a
Long-term Mg2+ imaging during apoptosis using a HaloTag-coupled Mg2+ probe demonstrated a Mg2+ concentration increase caused by dissociation of Mg2+ from ATP.
Highly selective tridentate fluorescent probes for visualizing intracellular Mg2+ dynamics without interference from Ca2+ fluctuation.
We developed highly selective fluorescent Mg2+ probes based on a novel tridentate Mg2+-selective chelator. The superior selectivity for Mg2+ over Ca2+ enabled the detection of intracellular Mg2+Expand
Ratiometric Imaging of Intracellular Mg2+ Dynamics Using a Red Fluorescent Turn-off Probe and a Green Fluorescent Turn-on Probe
In this work, we developed a red fluorescent turn-off Mg2+ probe with high Mg2+ selectivity. The quenching response to Mg2+ in combination with a green fluorescent turn-on Mg2+ probe enabled aExpand
Single-cell dynamics of pannexin-1-facilitated programmed ATP loss during apoptosis
ATP is essential for all living cells. However, how dead cells lose ATP has not been well investigated. In this study, we developed new FRET biosensors for dual imaging of intracellular ATP level andExpand
Single-cell dynamics of pannexin-1-facilitated programmed ATP loss during apoptosis
ATP is essential for all living cells. However, how dead cells lose ATP has not been well investigated. In this study, we developed new FRET biosensors for dual imaging of intracellular ATP level andExpand