Yusuke Kabuki

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The purpose of the present study was to clarify the central nervous system function of amino acids during acute stress. In Experiment 1, changes in free amino acid pattern were investigated in the brain of neonatal chicks exposed to either restraint with isolation-induced or fasting stress. l-Proline and l-arginine were decreased in the telencephalon and(More)
To clarify whether L-ornithine and/or its metabolite involves sedative and hypnotic effects under social separation stress, the effects of intracerebroventricular (i.c.v.) injection of L-ornithine and polyamines (putrescine, spermidine and spermine) were compared in chicks. Birds were injected i.c.v. with 0.5 mumol of L-ornithine, putrescine, spermidine,(More)
L-Serine is considered a functional amino acid in the central nervous system, since intracerebroventricular injection of L-serine induced sedative and hypnotic effects in neonatal chicks exposed to acute stressful conditions. Accordingly, L-serine is a candidate anti-stress factor, but the effect of daily intake of L-serine on behavior of animals exposed to(More)
Chronic stress induces abnormal mental state and behavior, and can be a risk factor for mental disorders. Although it is reported that l-tyrosine, an amino acid that is a precursor of catecholamine synthesis, alleviated the change of cognition and behavior induced by acute stress, knowledge about its effects on chronic stress is limited. In the present(More)
Using microdialysis, we investigated the effect of l-proline on monoamine release in the medio-rostral neostriatum/hyperstriatum ventrale (MNH) of freely moving and restricted chicks. A 30 min handling-stress resulted in a significant increase in extracellular homovallinic acid (HVA), a dopamine metabolite, and 5-hydroxyindoleacetic acid (5-HIAA), a(More)
The Roborovskii hamster (Phodopus roborovskii) has been shown to have high locomotor activity (hyperactivity) and low dopamine concentrations in the brain. We hypothesized that low brain dopamine concentrations play a role in the pathogenesis of hyperactivity. In this study, therefore, we investigated the effects of L-DOPA (L-3,4-dihydroxyphenylalanine),(More)
The Roborovskii hamster (Phodopus roborovskii) has high locomotor activity (hyperactivity) and low dopamine levels in the brain compared with the congeneric Djungarian hamster (Phodopus sungorus). To clarify the efficacy of dietary l-tyrosine in ameliorating signs of hyperactivity, we investigated the effects of chronic administration of l-tyrosine, the(More)
Two species of the genus Phodopus, Djungarian hamster (P. sungorus) and Roborovskii hamster (P. roborovskii), differ in their behavior. The Roborovskii hamster has high locomotor activity (hyperactivity) compared to the Djungarian hamster. In this study, we compared locomotor activity of the hamsters in different environments, and compared their brain(More)
1. The purpose of the present study was to clarify brain monoamine metabolism during two different conditions of acute stress by quantifying changes in the brain of neonatal chicks exposed to either restraint with isolation, or fasting stress. 2. Under restraint with isolation-induced stress, dopaminergic metabolism was clearly stimulated. 3. During(More)
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