Yushin Nakamura

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We designed novel PNA monomer units that could post-synthetically and quantitatively introduce photo-functionalized molecules into PNA oligomers. Designed photo-functionalized PNAs were applicable to wide fields such as genome based analysis. In this study, we applied a photo-functionalized PNA oligomers for the detection of transcription factors binding(More)
function; \codon dialect" found for individual unicellular organisms [1]. Taxonomically related organisms have similar dialects but those distantly related have distinct ones. For example, characteristics of E. coli codon{choice (E. coli dialect) di er considerably from those of yeast S. cerevisiae, but are similar to those of Salmonella. By measuring(More)
We have designed a novel fluorescent PNA probe which can be rapidly introduced into the living cell without any complicated pretreatment. We could post-synthetically incorporate amino acid derivatives having membrane permeability function into the PNA probe by utilizing key compound 1 which we have already developed. We show that the PNA probe will be a(More)
We have designed a novel dual-labeled PNA oligomer, having both a fluorescent dye and a quencher, by utilizing key compounds 1 and 2. We showed that the designed dual-labeled PNA oligomer works as a molecular beacon PNA. We also investigated the optimization of a stem-loop structure which can supersensitize the function as a molecular beacon PNA.
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