Yuri V Gavrilov

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Although sleep-wake disturbances are prevalent and well described after traumatic brain injury, their pathophysiology remains unclear, most likely because human traumatic brain injury is a highly heterogeneous entity that makes the systematic study of sleep-wake disturbances in relation to trauma-induced histological changes a challenging task. Despite(More)
STUDY OBJECTIVES Coma and chronic sleepiness are common after traumatic brain injury (TBI). Here, we explored whether injury to arousal-promoting brainstem neurons occurs in patients with fatal TBI. METHODS Postmortem examination of 8 TBI patients and 10 controls. RESULTS Compared to controls, TBI patients had 17% fewer serotonergic neurons in the(More)
Objective Multiple sleep onset rapid eye movement (R) periods (SOREMPs) and a mean sleep latency ≤8min on the multiple sleep latency test (MSLT) are diagnostic criteria of narcolepsy (NC), but occur also in other conditions with increased sleep pressure, including insufficient sleep syndrome (ISS), sleep disordered breathing (SDB) or Parkinson's disease(More)
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