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Cardiac and neuronal G protein-activated K+ channels (GIRK; Kir3) open following the binding of Gbetagamma subunits, released from Gi/o proteins activated by neurotransmitters. GIRKs also possess basal activity contributing to the resting potential in neurons. It appears to depend largely on free Gbetagamma, but a Gbetagamma-independent component has also(More)
G protein-activated K(+) channels (GIRKs; Kir3) are activated by direct binding of Gbetagamma subunits released from heterotrimeric G proteins. In native tissues, only pertussis toxin-sensitive G proteins of the G(i/o) family, preferably Galpha(i3) and Galpha(i2), are donors of Gbetagamma for GIRK. How this specificity is achieved is not known. Here, using(More)
In this and the associated article BioBlender: A Software for Intuitive Representation of Surface Properties of Biomolecules [1], we present BioBlender as a complete instrument for the elaboration of motion (here) and the visualization [1] of proteins and other macromolecules, using instruments of computer graphics. A vast number of protein (if not most)(More)
The problem of protein conformation motion modeling is an open problem in the structural computational biology. It is difficult to solve it using methods of molecular dynamics or quantum physics because these methods deal with time intervals of nanoseconds or microseconds, while conformation motions take time of millisecond order. In addition, these methods(More)
The goals and objectives of some topics of structural bioinformatics are presented in the article. The main methods and approaches used in computer biology are highlighted. Areas in which bioinformatic science can greatly facilitate and speed up the work of practical biologist and pharmacologist are revealed. The features of both the basic packages and(More)
Succinic semialdehyde dehydrogenase (SSADH) converts succinic semialdehyde (SSA) to succinic acid in the mitochondrial matrix and is involved in the metabolism of the inhibitory neurotransmitter γ-aminobutyric acid (GABA). The molecular structure of human SSADH revealed the intrinsic regulatory mechanism--redox-switch modulation--by which large(More)
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