Current Concept and Update of the Macrophage Plasticity Concept: Intracellular Mechanisms of Reprogramming and M3 Macrophage “Switch” Phenotype
- I. MalyshevYuri Malyshev
- 23 August 2015
Biology, Medicine
It is hypothesized that, in addition to the M1 and M2 phenotypes, an M3 switch phenotype exists that responds to proinflammatory stimuli with reprogramming towards the anti-inflammatory M2 phenotype, and signs of such a switch phenotype in lung diseases are found.
M3 Macrophages Stop Division of Tumor Cells In Vitro and Extend Survival of Mice with Ehrlich Ascites Carcinoma
- S. KalishS. LyaminaE. ManukhinaYuri MalyshevA. RaetskayaI. Malyshev
- 26 January 2017
Biology, Medicine
Development of new biotechnologies for restriction of tumor growth using in vitro reprogrammed M3 macrophages is very promising.
C57BL/6N Mice Are More Resistant to Ehrlich Ascites Tumors Than C57BL/6J Mice: The Role of Macrophage Nitric Oxide
- S. KalishS. Lyamina I. Malyshev
- 20 October 2015
Biology, Medicine
The vulnerability to the tumor development can be predetermined by genetic characteristics of the NO generation system in macrophages, and the important role of NO in anti-EAC immunity should be taken into account in elaboration of new antitumor therapies.