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External validation of IMP3 expression as an independent prognostic marker for metastatic progression and death for patients with clear cell renal cell carcinoma
High‐quality external validation studies have recently been highlighted to be of paramount importance for proper translation of prognostic markers into the clinical setting. To that end, the authors… Expand
Carbonic anhydrase IX is not an independent predictor of outcome for patients with clear cell renal cell carcinoma.
- B. Leibovich, Yuri M. Sheinin, +4 authors E. Kwon
- Journal of clinical oncology : official journal…
- 20 October 2007
PURPOSE Expression of carbonic anhydrase IX (CAIX) has been reported to be an independent predictor of outcome and is being investigated as a therapeutic target for patients with clear cell renal… Expand
RAC1 GTPase promotes the survival of breast cancer cells in response to hyper-fractionated radiation treatment
Radiation therapy is a staple approach for cancer treatment, whereas radioresistance of cancer cells remains a substantial clinical problem. In response to ionizing radiation (IR) induced DNA damage,… Expand
B7-H1 Expression in Malignant Pleural Mesothelioma is Associated with Sarcomatoid Histology and Poor Prognosis
- A. Mansfield, A. Roden, +5 authors E. Kwon
- Journal of thoracic oncology : official…
- 1 July 2014
Introduction: B7 homolog 1 (B7-H1; aka programmed cell death 1 ligand 1) is a negative costimulatory molecule that is associated with poor prognosis in many tumor types. Given the poor prognosis and… Expand
Development and evaluation of BioScore
The authors previously showed that increased tumor expression levels of B7‐H1, survivin, and Ki‐67 are independent predictors of poor outcome for patients with clear cell renal cell carcinoma… Expand
Ki‐67 and coagulative tumor necrosis are independent predictors of poor outcome for patients with clear cell renal cell carcinoma and not surrogates for each other
Ki‐67 is a cell proliferation protein associated with aggressive clear cell renal cell carcinoma (ccRCC). A recent report suggests that Ki‐67 may represent a surrogate marker for coagulative tumor… Expand
Hormone receptor expression in renal angiomyolipoma: clinicopathologic correlation.
- Stephen A. Boorjian, Yuri M. Sheinin, Paul L. Crispen, Christine M. Lohse, Eugene D. Kwon, B. Leibovich
- 1 October 2008
OBJECTIVES Although renal angiomyolipoma (AML) occurs more commonly in females than males, the origin of this difference in incidence by sex is unknown. Therefore, we investigated the expression of… Expand
Tissue microarrays: one size does not fit all
- J. Eckel-Passow, C. Lohse, Yuri M. Sheinin, P. Crispen, C. Krco, E. Kwon
- Diagnostic pathology
- 7 July 2010
BackgroundAlthough tissue microarrays (TMAs) are commonly employed in clinical and basic-science research, there are no guidelines for evaluating the appropriateness of a TMA for a given biomarker… Expand
Amyloid precursor-like protein 2 (APLP2) affects the actin cytoskeleton and increases pancreatic cancer growth and metastasis
Amyloid precursor-like protein 2 (APLP2) is aberrantly expressed in pancreatic cancer. Here we showed that APLP2 is increased in pancreatic cancer metastases, particularly in metastatic lesions found… Expand
PR55α Subunit of Protein Phosphatase 2A Supports the Tumorigenic and Metastatic Potential of Pancreatic Cancer Cells by Sustaining Hyperactive Oncogenic Signaling.
The protein phosphatase 2 (PP2A) holoenzyme consists of a catalytic subunit, a scaffold subunit, and a regulatory subunit. Based on loss-of-function analysis using PP2A catalytic inhibitors or… Expand