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- Sushmita Roy, Jason Ernst, +93 authors Manolis Kellis
- Science
- 2010
To gain insight into how genomic information is translated into cellular and developmental programs, the Drosophila model organism Encyclopedia of DNA Elements (modENCODE) project is comprehensively… (More)
- Yuri B. Schwartz, Vincenzo Pirrotta
- Nature Reviews Genetics
- 2007
Polycomb group complexes, which are known to regulate homeotic genes, have now been found to control hundreds of other genes in mammals and insects. First believed to progressively assemble and… (More)
- Peter V. Kharchenko, Artyom A. Alekseyenko, +27 authors Peter J. Park
- Nature
- 2011
Chromatin is composed of DNA and a variety of modified histones and non-histone proteins, which have an impact on cell differentiation, gene regulation and other key cellular processes. Here we… (More)
- Yuri B. Schwartz, Tatyana G. Kahn, Per Stenberg, Katsuhito Ohno, Richard Bourgon, Vincenzo Pirrotta
- PLoS genetics
- 2010
Polycomb (PcG) regulation has been thought to produce stable long-term gene silencing. Genomic analyses in Drosophila and mammals, however, have shown that it targets many genes, which can switch… (More)
- Cheri A. Schaaf, Ziva Misulovin, +6 authors Dale Dorsett
- PloS one
- 2009
The cohesin protein complex was first recognized for holding sister chromatids together and ensuring proper chromosome segregation. Cohesin also regulates gene expression, but the mechanisms are… (More)
- Yuri B. Schwartz, Vincenzo Pirrotta
- Nature Reviews Genetics
- 2013
Polycomb group (PcG) proteins are epigenetic repressors that are essential for the transcriptional control of cell differentiation and development. PcG-mediated repression is associated with specific… (More)
- Yuri B. Schwartz, Tatyana G. Kahn, +4 authors Vincenzo Pirrotta
- Nature Genetics
- 2006
Polycomb group (PcG) complexes are multiprotein assemblages that bind to chromatin and establish chromatin states leading to epigenetic silencing. PcG proteins regulate homeotic genes in flies and… (More)
- Ziva Misulovin, Yuri B. Schwartz, +8 authors Dale Dorsett
- Chromosoma
- 2007
The cohesin complex is a chromosomal component required for sister chromatid cohesion that is conserved from yeast to man. The similarly conserved Nipped-B protein is needed for cohesin to bind to… (More)
- Nicole C. Riddle, Aki Minoda, +15 authors Gary H. Karpen
- Genome research
- 2011
Eukaryotic genomes are packaged in two basic forms, euchromatin and heterochromatin. We have examined the composition and organization of Drosophila melanogaster heterochromatin in different cell… (More)
- Thea A. Egelhofer, Aki Minoda, +30 authors Jason D. Lieb
- Nature Structural &Molecular Biology
- 2011
We have tested the specificity and utility of more than 200 antibodies raised against 57 different histone modifications in Drosophila melanogaster, Caenorhabditis elegans and human cells. Although… (More)