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Mutated K-ras activates CDK8 to stimulate the epithelial-to-mesenchymal transition in pancreatic cancer in part via the Wnt/β-catenin signaling pathway.
MRI-Based Radiomics Predicts Tumor Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer
The machine learning radiomics model based on the commonly used T2-weighted images on pelvic Magnetic Resonance Imaging (MRI) scans has the potential to be adapted in clinical practice and achieves a satisfactory overall diagnostic accuracy for predicting of pCR, good response, and down-staging.
Significance of inflammation-based indices in the prognosis of patients with non-metastatic colorectal cancer
Results highlight the usefulness of the coNLR-PDW index as a prognostic marker of non-metastatic CRC outcome and could contribute to establishing more personalized regimes for patients undergoing tumor resection surgery.
Neuron navigator 2 overexpression indicates poor prognosis of colorectal cancer and promotes invasion through the SSH1L/cofilin-1 pathway
In vitro and in vivo assays demonstrated that knockdown of NAV2 led to reduced migration and invasion of cancer cells, and the process involved the regulation of F-actin polymerization through the SSH1L/cofilin-1 pathway.
A bibliometric analysis of 23,492 publications on rectal cancer by machine learning: basic medical research is needed
The number of publications indexed on RC has expanded rapidly over the past 25 years and studies on basic research, postoperative quality of life and cost-effective research were relatively lacking, it is predicted thatbasic research, inflammation and some other research fields might become the potential hotspots in the future.
Nomograms for prediction of overall and cancer-specific survival in young breast cancer
These nomograms provided more accurate individualized risk prediction of OS and BCSS and may assist clinicians in making decisions for young patients with BC.
Has the increase in the regional nodes evaluated improved survival rates for patients with locoregional colon cancer?
The golden period of surgical development in colon cancer, using RNE as an alternative indicator, occurred in the first decade of the 21st century, but the increase of RNE does not provide survival benefits for locoregional colon cancer.
Predicting pathological complete response by comparing MRI‐based radiomics pre‐ and postneoadjuvant radiotherapy for locally advanced rectal cancer
Total mesorectal excision following neoadjuvant chemoradiotherapy (nCRT) is recommended in the latest treatment of locally advanced rectal cancer (LARC).
Inhibition of SW620 human colon cancer cells by upregulating miRNA-145.
- Chen Li, Na Xu, Yuqiang Li, Yu Wang, Zhi-tu Zhu
- Biology, MedicineWorld journal of gastroenterology
- 7 March 2016
AIM To investigate the targeted inhibition of proliferation and migration of SW620 human colon cancer cells by upregulating miRNA-145 (miR-145). METHODS Forty-five samples of colon cancer tissues…
lncRNA SNHG4 modulates colorectal cancer cell cycle and cell proliferation through regulating miR-590-3p/CDK1 axis
The long noncoding RNA SNHG4 was dramatically increased in CRC tissue samples and cell lines based on both publicly available and experimental data and relieved the miR-590-3p-induced inhibition of CDK1 by acting as a competing endogenous RNA (ceRNA).