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Recent evidence shows that the outcome of rescue intracytoplasmic sperm injection (ICSI) is unsatisfactory on account of a poor clinical pregnancy rate. These outcomes may be due to either the in-vitro ageing of cultured oocytes before ICSI or the asynchrony between the embryo developmental stage and the endometrial secretory pattern. To address the latter(More)
To assess the impact of one–two blastomeres lysis on the viability of thawed day 3 human embryos. A retrospective analysis was performed on 248 frozen-thawed embryo replacement cycles in which all embryos were frozen at day 3 at the seven–eight cell stage with ≤10% fragmentation. Outcomes of transfer cycles with fully intact embryos (intact group) were(More)
Due to the rapid advancement of supercomputing hardware, there is a growing interest in parallel algorithms for modeling the full three dimensional interaction between the blood flow and the arterial wall. In [4], Barker and Cai developed a parallel framework for solving fluid-structure interaction problems in two dimensions. In this paper, we extend the(More)
PolyA– RNAs have not been widely analyzed in human pre-implantation embryos due to the scarcity of materials. In particular, circular RNA (circRNA), a novel type of polyA– RNA, has not been characterized during human pre-implantation development. We systematically analyze polyA+ messenger RNAs (mRNAs) and polyA– RNAs in individual human oocytes and(More)
Computer modeling of blood flows in the arteries is an important and very challenging problem. In order to understand, computationally, the sophisticated hemodynamics in the arteries, it is essential to couple the fluid flow and the elastic wall structure effectively and specify physiologically realistic boundary conditions. The computation is expensive and(More)
Direct numerical simulation of three-dimensional incompressible flows at high Reynolds number using the unsteady Navier-Stokes equations is challenging. In order to obtain accurate simulations, very fine meshes are necessary, and such simulations are increasingly important for modern engineering practices, such as understanding the flow behavior around high(More)
MicroRNAs (miRNAs) are short non-coding RNAs that play important roles in basic cellular processes, including differentiation, proliferation, apoptosis and autophagy. They are also involved in various stages of tumorigenesis and play key roles in bladder cancer initiation and progression. Notably, the altered expression of miRNAs in the tumors is reflected(More)
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