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An improved 2D weighted centroid localization algorithm for Wireless Sensor Networks (WSNs) is proposed. Compared with most previous approaches, the improved algorithm uses a optimized threshold to restrict the number of anchors involved. Simulation results show that our improved weighted centroid localization algorithm increased the positioning accuracy by(More)
Histone deacetylases are a class of enzymes that play important roles in post translational modifications of histones by deacetylating the lysine residues as well as interacting with various non-histone proteins. This type of enzymes is closely related to oncogenesis and has been proved to be attractive targets for designing novel anti-cancer agents. Over(More)
Tamibarotene (Am80), a poorly water-soluble drug for the treatment of acute promyelocytic leukemia (APL), loaded nanostructured lipid carrier (Am80-NLC) was developed and characterized previously. The purpose of the present work was to develop PEGylated nanostructured lipid carrier (PEG-NLC) for intravenous delivery of Am80, with the aim to further extend(More)
Pharmacological inhibition of histone deacetylases (HDACs) has been successfully applied in the treatment of a wide range of disorders, including Parkinson's disease, infection, cardiac diseases, inflammation, and especially cancer. HDAC inhibitors (HDACIs) have been proved to be effective antitumor agents by various stages of investigation. At present,(More)
Semiconductor manufacturers provide low-cost, low-power and short-range solutions for the application of Wireless Sensor Network (WSN), such as ZigBee, Bluetooth, Wi-Fi etc. The quality of radio frequency signal, which carries information in wireless communication channel, is the key to WSN. But it is easily influenced by the external environment. Received(More)
Inhibition of histone deacetylases (HDACs) has diverse effects on cell function, such as causing differentiation, growth arrest and apoptosis in nearly all types of tumor cell lines. In our previous work, we have designed and synthesized a novel series of 4-hydroxycinnamamide-based and 3-hydroxycinnamamide-based HDAC inhibitors (HDACIs), among which,(More)
We designed and synthesized a novel mutual prodrug, named BC-01 (3), by integrating ubenimex and Fluorouracil (5-FU) into one molecule based on prior research results that showed that a combination of the aminopeptidase N (CD13) inhibitor, ubenimex, and the cytotoxic antitumor agent, 5-FU, exhibited improved in vitro and in vivo antitumor efficiency. 3(More)
In our efforts of developing novel compounds as potential anticancer agents, a series of tamibarotene analogs containing Zn(2+) -binding moieties were designed and developed. Biological characterization identified compound 7b as the most potent one with improved antiproliferative activities against multiple cancer cell lines, compared to parent compound(More)
A series of novel α-sulfonyl γ-(glycinyl-amino)proline peptidomimetic derivatives were designed, synthesized and assayed for their activities against matrix metalloproteinase-2 (MMP-2), aminopeptidase N (APN)/CD13 and HDACs. The results indicated that all the compounds exhibited highly selective inhibition against MMP-2 as compared with APN and HDACs. The(More)
Frameless thin film photovoltaic module is mounted to metal rails by acrylic tape. Theoretical and FEA simulation show that the bonded rail mounting configuration can be modeled as beam series consisting of cantilever beams and fixed-fixed beams. A design rule was found for the relationship between tape-to-tape spacing and tape to glass edge spacing. The(More)