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Two major challenges of current photodynamic therapy (PDT) are the limited tissue penetration of excitation light and poor tumor-selectivity of the photosensitizer (PS). To address these issues, we developed a multifunctional nanoconstruct consisting of upconversion nanoparticles (UCNPs) that transform near-infrared (NIR) light to visible light and a(More)
TNFa seems to have an important role in the clinical severity of several fatal parasitic diseases such as cerebral malaria (Grau et al. 1989) and hepatic schistosomiasis (Amiri et al. 1992). At least two allelic forms exist in the TNFA gene promoter region, TNF1 and TNF2, and the latter allele upregulates TNFA transcription efficiency (Wilson et al. 1994).(More)
The presence and diversity of acyl homoserine lactone (AHL)-producers in an urban river biofilm were investigated during 60-day biofilm formation. AHL biosensors detected the presence of AHL-producers in 1–60-day river biofilms. Screening for AHL-producers resulted in 17 Aeromonas spp., 3 Pseudomonas spp., 3 Ensifer spp., and 1 Acinetobacter sp. Among these(More)
BACKGROUND Physicians' poor mental health not only hinders their professional performance and affects the quality of healthcare provided but also adversely affects patients' health outcomes. Few studies in China have evaluated the mental health of physicians. The purposes of this study are to quantify Chinese physicians' anxiety and depressive symptoms as(More)
The aim was to explore the potential application of novel self-assembled nanoparticles cross-linking thermosensitive hydrogels composed of polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol (Soluplus) and tacrolimus (FK-506) for local therapy of rheumatoid arthritis (RA). The sol-gel transition temperature (Tsol-gel), gelation time, rheological(More)
In this manuscript, a near-infrared (NIR) light-breakable amphiphilic block copolymer N-succinyl-N'-4-(2-nitrobenzyloxy)-succinyl-chitosan micelles (SNSC), containing light-sensitive triggering group 2-nitrobenzyl alcohol on the hydrophobic block, was developed. The UV-Vis absorption spectra, Fourier Transform Infrared (FTIR) spectra, and (1)H nuclear(More)
DNA methylation is dynamically reprogrammed during early embryonic development in mammals. It can be explained partially by the discovery of 5-(hydroxymethyl)cytosine (5-hmC), 5-formylcytosine (5-fC), and 5-carboxylcytosine (5-caC), which are identified as key players involved in both active and passive demethylation pathways. As one of the ten-eleven(More)
Orthogonal dual-pulse laser-ablation laser-induced breakdown spectroscopy was first used to determine the laser-ablation threshold of samples. In this technique, the first laser pulse was used to ablate samples and the second time-delayed laser pulse was used to break down the ablated samples. Orthogonal geometric arrangement was adopted in this technique(More)
Existence of G-quadruplex DNA in vivo always attract widespread interest in the field of biology and biological chemistry. We reported our findings for the existence of G-quadruplex structures in promoter region of oncogenes confirmed by G-quadruplex DNA cross-linking strategy. Probes for selective G-quadruplex cross-linking was designed and synthesized(More)
Poor mental health among nurses not only hinders professional performance but also affects the quality of healthcare provided. To improve the prevention and management of depression among nurses in mainland China, we investigated the association between working conditions and depressive symptoms using a cross-sectional study with a sample of 3474 nurses(More)