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Adjuvant Corticosteroid Treatment in Adults With Influenza A (H7N9) Viral Pneumonia*
TLDR
High-dose corticosteroid therapy significantly increased both 30-day and 60-day mortality and longer viral shedding in patients with influenza A (H7N9) viral pneumonia, whereas no significant impact was observed for low-to-moderate doses of Corticosteroids. Expand
Disease-specific dynamic biomarkers selected by integrating inflammatory mediators with clinical informatics in ARDS patients with severe pneumonia
TLDR
Higher levels of inflammatory mediators were associated with poor survival rates in patients with lung cancer and involved in the process of the epithelial mesenchymal transition of alveolar epithelial cells. Expand
First identification of coexistence of blaNDM-1 and blaCMY-42 among Escherichia coli ST167 clinical isolates
TLDR
Systemic surveillance should focus on the dissemination of blaNDM-1 among Enterobacteriaceae, especially E. coli ST167 clone associated with animal infection. Expand
Thalidomide Combined with Low-dose Glucocorticoid in the Treatment of COVID-19 Pneumonia
TLDR
This work aims to provide a history of liver cancer research in China and its role in women's health since the 1950s and the role of chemotherapy in the development of type 2 diabetes is studied. Expand
Apatinib in patients with extensive-stage small-cell lung cancer after second-line or third-line chemotherapy: a phase II, single-arm, multicentre, prospective study
TLDR
This study aimed to investigate the efficacy and safety of apatinib in patients with extensive-stage SCLC who had progressed after two or three previous therapies and exhibited efficacy and an acceptable safety profile in previously heavily-treated ES-SCLC patients. Expand
Autophagy maintains the integrity of endothelial barrier in LPS‐induced lung injury
TLDR
It appears that autophagy played a protective role in LPS‐LI in part through restricting the injury of lung microvascular barrier. Expand
Gefapixant in two randomised dose-escalation studies in chronic cough
TLDR
P2X3 antagonism with gefapixant demonstrates anti-tussive efficacy and improved tolerability at lower doses than previously investigated, and patients with refractory chronic cough had significant reductions in coughing with lower doses of gefAPixant. Expand
Protective effects of hesperetin on lipopolysaccharide‐induced acute lung injury by targeting MD2
TLDR
HES showed a significantly protective effect against LPS‐induced ALI, which might be associated with MD2 protein, attested HES worthy of further progress into an adjunctive potential drug for the treatment for ALI. Expand
A global view of regulatory networks in lung cancer: An approach to understand homogeneity and heterogeneity.
TLDR
Subtype-specific TF gene regulatory networks with elements should be an alternative for diagnostic and therapeutic targets for early identification of lung cancer and can provide insightful clues to etiology and pathogenesis. Expand
ctDNA assessment of EGFR mutation status in Chinese patients with advanced non-small cell lung cancer in real-world setting.
TLDR
Multivariate analysis showed female, chemotherapy-naïve, or ≥2 metastatic organs patients had higher EGFR mutation rate, and ctDNA based EGFR mutations test is feasible and could be a surrogate when tissue biopsy is not available. Expand
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