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Adaptive immune response of Vgamma2Vdelta2+ T cells during mycobacterial infections.
To examine the role of T cell receptor (TCR) in gammadelta T cells in adaptive immunity, a macaque model was used to follow Vgamma2Vdelta2+ T cell responses to mycobacterial infections. These…
Adaptive Immune Response of Vγ2Vδ2+ T Cells During Mycobacterial Infections
This capacity to rapidly expand coincided with a clearance of BCG bacteremia and immunity to fatal tuberculosis in BCG-vaccinated macaques, thus, Vγ2Vδ2+ T cells may contribute to adaptive immunity to mycobacterial infections.
Keratinocyte-releasable stratifin functions as a potent collagenase-stimulating factor in fibroblasts.
- A. Ghahary, Feridoun Karimi-Busheri, M. Weinfeld
- Biology, MedicineThe Journal of investigative dermatology
- 1 May 2004
A keratinocyte-releasable form of stratifin in KCM that mimics the collagenase stimulatory effect of KCM for dermal fibroblasts is identified.
14-3-3σ associates with cell surface aminopeptidase N in the regulation of matrix metalloproteinase-1
Evidence is provided that APN is a novel cell surface receptor for stratifin and a potential target in the regulation of MMP-1 expression in epithelial–stromal cell communication.
Differentiated keratinocyte-releasable stratifin (14-3-3 sigma) stimulates MMP-1 expression in dermal fibroblasts.
Evidence is provided that keratinocytes express a high level of 14-3-3sigma at the levels of mRNA and protein, which is also known as stratifin.
Fibroblast extracellular matrix gene expression in response to keratinocyte‐releasable stratifin
- A. Ghaffari, Yunyaun Li, A. Karami, M. Ghaffari, E. Tredget, A. Ghahary
- BiologyJournal of cellular biochemistry
- 15 May 2006
The results suggest that keratinocyte‐releasable stratifin plays a major role in induction of ECM degradation by dermal fibroblasts through stimulation of key MMPs, such as M MP‐1 and MMP‐3.