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Kinesin is a stepping motor that successively produces forward and backward 8-nm steps along microtubules. Under physiological conditions, the steps powering kinesin's motility are biased in one direction and drive various biological motile processes. So far, the physical mechanism underlying the unidirectional bias of the kinesin is not fully understood.(More)
Experimental data suggest that mitochondria is involved in tumorigenesis. However, little is known about the qualitative and quantitative changes of mtDNA in colorectal cancer tissues. We therefore conducted possible correlations of the mitochondrial DNA (mtDNA) copy number in colorectal cancer (CRC) with clinical and pathological findings and CRC(More)
Molecular motors are single macromolecules that generate forces at the pi-conewton range and nanometer scale. They convert chemical energy into mechanical work by moving along filamentous structures. In this paper, we study the velocity of two-head molecular motors in the framework of a mechanochem-ical network theory. The network model, a generalization of(More)
Promoter strength, or activity, is important in genetic engineering and synthetic biology. A constitutive promoter with a certain strength for one given RNA can often be reused for other RNAs. Therefore, the strength of one promoter is mainly determined by its nucleotide sequence. One of the main difficulties in genetic engineering and synthetic biology is(More)
The transport of organelles and other cargoes in living cells has been described by a kinetic tug-of-war model advanced by Müller, Klumpp, and Lipowsky, in which, as a function of time, t, a team of n+ (t)=0,1,⋯,N+ molecular motors may attach a cargo to a filamentous track and pull it towards the plus end in competition with n- (t)=0,1,⋯,N- motors that pull(More)
  • Yunxin Zhang
  • 2011
In a cell, organelles and vesicles are usually transported by cooperation of several motor proteins, including plus-end-directed motor kinesin and minus-end-directed motor dynein. In recent years, many biophysical models have been constructed to understand the mechanism of this transport; however, so far, its basic principle has not been completely(More)
In this study, a two-state mechanochemical model is presented to describe the dynamic instability of microtubules (MTs) in cells. The MT switches between two states, the assembly and disassembly states. In assembly state, the growth of MTs includes two processes: free GTP-tubulin binding to the tip of protofilament (PF) and conformation change of PF, during(More)
Bladder cancer-specific oncolytic adenovirus Ad/PSCAE/UPII/E1A, carrying E1A gene regulated by human Uroplakin II (UPII) promoter and prostate stem cell antigen enhancer (PSCAE), could kill bladder tumor cells preferentially. The aim of this study was to examine the effects of Ad/PSCAE/UPII/E1A combined with cisplatin on human bladder cancer cells and to(More)