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Autophagy is an evolutionarily conserved process that mediates the degradation of abnormal proteins and the removal of dysfunctional organelles. Recently, accumulating evidence has implicated the dysregulation of autophagy as underlying the pathophysiology of several neurodegenerative diseases. Using culture models of Parkinson's disease, we have(More)
Bak is a prototypic pro-apoptotic Bcl-2 family protein expressed in a wide variety of tissues and cells. Recent studies have revealed that Bcl-2 family proteins regulate apoptosis as well as autophagy. To investigate whether and how Bak exerts a regulatory role on autophagy-related events, we treated independent cell lines, including MN9D neuronal cells,(More)
When an Original Equipment Manufacturer (OEM), which makes a final product for the consumer marketplace by purchasing components from its suppliers, faces unexpected supply network failures and market events, models of manufacturing service capabilities can provide information required for efficient recovery of these supply network. Models of manufacturing(More)
Apache Spark framework, which is the implementation of Resilient Distributed Datasets(RDD), is used instead of MapReduce on recent data processing models of Hadoop ecosystem. In this paper, we evaluated the performance and resource usage of real world workloads on scale-up and scale-out clusters using the in-memory caching feature of Spark framework. In our(More)
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