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Distinct transcriptional regulation and function of the human BACE2 and BACE1 genes
TLDR
The data argue against BACE2 being involved in the formation of neuritic plaques in AD and indicate that despite being homologous in amino acid sequence, Bace2 and BACE1 have distinct functions and transcriptional regulation.
Hereditary features, treatment, and prognosis of the lipoprotein glomerulopathy in patients with the APOE Kyoto mutation.
TLDR
Fenofibrate can induce lipoprotein glomerulopathy remission and the fibrate effects depend on the degree of lipid control and baseline proteinuria, and normalization of serum apoE and triglycerides can be used to judge the efficacy of lipid-lowering treatment.
Microarray profiling of microRNAs expressed in testis tissues of developing primates
TLDR
PicTar and TargetScan prediction tools predicted a number of target mRNAs, and some of these target genes predicted by miRNAs have been shown to associate with spermatogenesis.
Piwil2 Suppresses P53 by Inducing Phosphorylation of Signal Transducer and Activator of Transcription 3 in Tumor Cells
TLDR
Human piwil2, or Hili represses the tumor suppressor P53 in human cancer cells and plays a role in anti-apoptosis in tumor cells possessing P53 as a positive regulator of STAT3 signaling pathway, providing novel sights into roles of Piwil2 in tumorigenesis.
Identification of piRNAs in Hela cells by massive parallel sequencing.
TLDR
It is demonstrated that HILI along with piRNAs plays a role in LINE1 suppression in HeLa cancer cell line.
Y chromosome haplogroups may confer susceptibility to partial AZFc deletions and deletion effect on spermatogenesis impairment.
TLDR
The findings indicate that some monophyletic Y chromosomes may be associated with predisposition to specific subtypes of partial AZFc deletion and adverse effect on spermatogenesis in a Chinese population.
Identification of novel mutations in Chinese Hans with autosomal dominant polycystic kidney disease
TLDR
Mutation study of PKD1 and PKD2 genes in Chinese Hans with ADPKD may contribute to a better understanding of the genetic diversity between different ethnic groups and enrich the mutation database.
Some single-nucleotide polymorphisms of the TSSK2 gene may be associated with human spermatogenesis impairment.
TLDR
To explore the possible association between mutations in the TSSK2 gene and idiopathic infertility in humans, mutation screening of the gene in 494 patients with azoospermia or severe oligozoospermia and 357 fertile controls was performed using denaturing high-performance liquid chromatography and DNA sequencing.
Common AZFc structure may possess the optimal spermatogenesis efficiency relative to the rearranged structures mediated by non-allele homologous recombination
TLDR
This finding implies that the overdose of AZFc NAHR-substrate may produce an additional risk for the massive AZFbc deletions during the multi-stage division process of germ cells and thus impair the global spermatogenesis efficiency in the carriers.
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