Yunqi Wang

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The Composite Information Systems Laboratory (CISL) at MIT is involved in research on the strategic, organizational and technical aspects of the integration of multiple heterogeneous database systems. In this paper we examine the scope of the work being done at CISL. Certain research efforts in the technical areas of system integration are emphasized; in(More)
This paper presents applications, requirements, an Information Technology (IT) architecture and a research agenda developed to facilitate connectivity among disparate information systems. The applications illustrate the benefits of connectivity as well as highlight problems encountered. These connectivity problems are organized into first-and second-order(More)
TGF-β modulates immune response by suppressing non-regulatory T (Treg) function and promoting Treg function. The question of whether TGF-β achieves distinct effects on non-Treg and Treg cells through discrete signaling pathways remains outstanding. In this study, we investigated the requirements of Smad-dependent and -independent TGF-β signaling for T-cell(More)
Naturally occurring regulatory T (nTreg) cells express Foxp3 and were originally discovered as immune suppressors critical for self-tolerance and immune homeostasis. Through yet-to-be-defined mechanisms, nTreg cells were recently shown to convert into proinflammatory cells. Particularly, attenuation of Foxp3 expression led to Th2 conversion of nTreg cells(More)
GATA-3 is a master regulator for T H 2 differentiation. It is however poorly understood if GATA-3 controls mature T cell function beyond T H 2 determination. We show that TCR signals and cytokine stimulation promoted GATA-3 expression in CD8 T cells, which controlled cell proliferation. While GATA-3-deficient CD8 T cells were generated, their peripheral(More)
BACKGROUND Malaria and AIDS represent 2 leading causes of death from infectious diseases worldwide, and their high geographic overlap means coinfection is prevalent. It remains unknown whether distinct immune responses during coinfection with malaria and human immunodeficiency virus (HIV) affect clinical outcomes. METHODS We tested this hypothesis by(More)
Many important applications require access to and integration of multiple disparate distributed information systems both within and across organizational boundaries. These types of application systems have been referred to as Composite Information Systems (CIS). This paper studies such heterogeneous distributed systems from the "where" perspective. Our(More)
BACKGROUND In vivo kinetics and frequencies of epitope-specific CD4 T cells in lymphoid compartments during M. tuberculosis infection and their resting memory pool after BCG vaccination remain unknown. METHODOLOGY/FINDINGS Macaque DR*W201 tetramer loaded with Ag85B peptide 65 was developed to directly measure epitope-specific CD4 T cells in blood and(More)
Separating the components of soil respiration and understanding the roles of abiotic factors at a temporal scale among different forest types are critical issues in forest ecosystem carbon cycling. This study quantified the proportions of autotrophic (RA) and heterotrophic (RH) in total soil (RT) respiration using trenching and litter removal. Field studies(More)
While recombinant Listeria monocytogenes strains can be explored as vaccine candidates, it is important to develop attenuated but highly immunogenic L. monocytogenes vaccine vectors. Here, prfA* mutations selected on the basis of upregulated expression of L. monocytogenes PrfA-dependent genes and proteins were assessed to determine their abilities to(More)