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Myosin-X provides a motor-based link between integrins and the cytoskeleton
Results indicate that Myo10-mediated relocalization of integrins might serve to form adhesive structures and thereby promote filopodial extension.
p21-activated Kinase 4 Phosphorylation of Integrin β5 Ser-759 and Ser-762 Regulates Cell Migration*
This report identified a unique PAK4-binding membrane-proximal integrin β5-SERS-motif involved in controlling cell attachment and migration and mapped the integrinβ5-binding site within PAK2, and found that PAK 4 binding to integrin αvβ5 was not sufficient to promote cell migration, but thatPAK4 kinase activity was required for PAK3 promotion of cell motility.
Kindlin 2 promotes breast cancer invasion via epigenetic silencing of the microRNA200 gene family
It is reported that Kindlin 2 markedly downregulates the expression of miR‐200 family by inducing CpG island hypermethylation and plays a novel role in epigenetic repression of miRNAs, a mechanism that promotes breast cancer invasion.
Kindlin 2 forms a transcriptional complex with β‐catenin and TCF4 to enhance Wnt signalling
The data indicate that Kindlins 2 is a new regulator of Wnt signalling, providing a mechanistic insight into the role of Kindlin 2 in cancer progression.
Opposite Role of Kindlin-1 and Kindlin-2 in Lung Cancers
Surprisingly, it is demonstrated that the very homologous Kindlin family proteins, Kindlin-1 and Kindlins-2 differentially regulate lung cancer cell progression and might block the invasive growth of large cell lung cancer.
HOXB9 acetylation at K27 is responsible for its suppression of colon cancer progression.
P21‐activated kinase 5 is overexpressed during colorectal cancer progression and regulates colorectal carcinoma cell adhesion and migration
It is demonstrated that PAK5 expression increased significantly with malignant progression of CRC and thatPAK5 might promote CRC metastasis by regulating CRC cell adhesion and migration.
Kindlin-2 induced by TGF-β signaling promotes pancreatic ductal adenocarcinoma progression through downregulation of transcriptional factor HOXB9.
Kindlin-2 controls sensitivity of prostate cancer cells to cisplatin-induced cell death.
Esculetin inhibits the proliferation of human lung cancer cells by targeting epithelial-to-mesenchymal transition of the cells.
- Hua Li, Qi Wang, Yunling Wang, Zekun Xu, Zh Han
- Biology, MedicineCellular and molecular biology
- 30 September 2019
It is demonstrated that esculetin effectively inhibits the proliferation of A549 cells, and regulates EMT of the cells via the down- regulation of vimentin and Snail, and up-regulation of E-cadherin expressions.