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Colorimetric and ratiometric fluorescence sensing of fluoride: tuning selectivity in proton transfer.
TLDR
Phenyl-1H-anthra[1,2-d]imidazole-6,11-dione and its derivatives have been investigated as new colorimetric and ratiometric fluorescent chemosensors for fluoride and shows the best selectivity.
PET imaging of microglia by targeting macrophage colony-stimulating factor 1 receptor (CSF1R)
TLDR
CPPC is a PET radiotracer specific for CSF1R, a microglia-specific marker that shows high and specific brain uptake in a murine and nonhuman primate lipopolysaccharide model of neuroinflammation and in postmortem brain tissue of patients with AD.
[(68) Ga]-HP-DO3A-nitroimidazole: a promising agent for PET detection of tumor hypoxia.
TLDR
The specificity of the agent for hypoxic tissues was further validated in a comparative study with a control compound, [(68) Ga]-HP-DO3A, which lacks the nitroimidazole moiety, and by PET imaging of tumor-bearing mice breathing air versus 100% O2 .
A selective fluorescent sensor for imaging Cd2+ in living cells.
Amplifying the sensitivity of zinc(II) responsive MRI contrast agents by altering water exchange rates.
TLDR
The new high relaxivity agents were used to successfully image Zn(II) release from the mouse pancreas in vivo during glucose stimulated insulin secretion and provide important insights into the interplay between structural modifications, water exchange rate, and kinetic stability properties of the sensors.
A europium(III)-based PARACEST agent for sensing singlet oxygen by MRI.
TLDR
The potential of using this probe to detect accumulation of the endoperoxide derivative in biological media by ratiometric CEST imaging was demonstrated.
Imaging Extracellular Lactate In Vitro and In Vivo Using CEST MRI and a Paramagnetic Shift Reagent.
TLDR
A relatively simple way to shift the lactate -OH proton resonance far away from water by addition of the paramagnetic shift reagent, EuDO3A, while retaining the CEST properties of lactate itself is demonstrated.
Fluorescence sensing of anions based on inhibition of excited-state intramolecular proton transfer.
TLDR
Interestingly, the different inhibition abilities of F-, CH3COO-, and H2PO4- produce different spectral behaviors in PUBO, so this new sensor successfully distinguishes the subtle difference in these three anionic substrates of similar basicity and surface charge density.
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