Yunjie Zhao

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Building tertiary structures of non-coding RNA is required to understand their functions and design new molecules. Current algorithms of RNA tertiary structure prediction give satisfactory accuracy only for small size and simple topology and many of them need manual manipulation. Here, we present an automated and fast program, 3dRNA, for RNA tertiary(More)
The connected vehicle research program is a multimodal research initiative in the U.S. that envisions a fully connected transportation system with wireless communications linking vehicles, the infrastructure, and handheld smart devices. This paper designs and evaluates a reservation-based approach to intersection control that is designed to take full(More)
The focus of this chapter is on issues surrounding the development and applications of large-scale agent-based traffic models. Following a brief overview of Agent-Based Modeling and Simulation (ABMS) applications in transportation modeling, the chapter proceeds to describe the authors' continued efforts and experiences with the development, calibration,(More)
Mammals and other complex organisms can transcribe an abundance of long non-coding RNAs (lncRNAs) that fulfill a wide variety of regulatory roles in many biological processes. These roles, including as scaffolds and as guides for protein-coding genes, mainly depend on the structure and expression level of lncRNAs. In this review, we focus on the current(More)
Riboswitches are novel RNA regulatory elements. Each riboswitch molecule consists of two domains: aptamer and express platform. The three-dimensional (3D) structure of the aptamer domain, depending on ligand binding or not, controls that of the express platform, which then switches on or off transcriptional or translational process. Here we study the two(More)
Riboswitches play roles in transcriptional or translational regulation through specific ligand binding of their aptamer domains. Although a number of ligand-bound aptamer complex structures have been solved, it is important to know ligand-free conformations of the aptamers in order to understand the mechanism of specific binding by ligands. In this paper,(More)