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It is now possible to record the EEG continuously during fMRI studies. This is a very promising methodology that combines knowledge about neuronal activity and its metabolic response. The EEG recorded inside the fMRI scanner is, however,heavily contaminated by artifacts caused by the high intensity magnetic field and rapidly changing field gradients.(More)
We studied single-event and average BOLD responses to EEG interictal epileptic discharges (IEDs) in four patients with focal epilepsy, using continuous EEG-fMRI during 80-min sessions. The detection of activated areas was performed by comparing the BOLD signal at each voxel to a model of the expected signal. Since little is known about the BOLD response to(More)
We investigated the early ("preattentive") cortical processing of voice information, using the so-called "mismatch response". This brain potential allows inferences to be made about the sensory short-term store. Most importantly, the mismatch potential also provides information about the organization of long-term memory traces in the auditory system. Such(More)
Invasive intracranial electroencephalography (EEG) studies help identify the epileptogenic focus and assess if the identified zone overlies eloquent cortex by means of cortical stimulation. Proper interpretation and use of the intracranial recording/stimulation studies requires an effective display of multimodal information. We developed a software system(More)
BACKGROUND NKX2-3 is associated with inflammatory bowel disease (IBD). NKX2-3 is expressed in microvascular endothelial cells and the muscularis mucosa of the gastrointestinal tract. Human intestinal microvascular endothelial cells (HIMECs) are actively involved in the pathogenesis of IBD and IBD-associated microvascular dysfunction. To understand the(More)
Adaptive filter implementations require real-time conversion of coefficients to canonical signed digit (CSD) or similar representations to benefit from multiplierless techniques for implementing filters. Multiplierless approaches are used to reduce the hardware and increase the throughput. This paper introduces a novel hardware implementation method that(More)
Burst suppression pattern (BSP) as a common diffuse abnormal electroencephalographic (EEG) pattern requires close monitoring in the intensive care unit (ICU) environments. Automatic detection of individual BS events has a clinical and practical importance for brain function monitoring in the neurological ICUs (NICUs) using Continuous EEG (CEEG). In this(More)
BACKGROUND Maintenance gefitinib significantly prolonged progression-free survival (PFS) compared with placebo in patients from eastern Asian with locally advanced/metastatic non-small-cell lung cancer (NSCLC) after four chemotherapeutic cycles (21 days per cycle) of first-line platinum-based combination chemotherapy without disease progression. The(More)