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AMPK activation serves a critical role in mitochondria quality control via modulating mitophagy in the heart under chronic hypoxia
- Huagang Zhang, Bo Liu, +6 authors Yingbin Xiao
- Biology, Medicine
- International journal of molecular medicine
- 26 October 2017
In the present study, mitophagy was activated and played a crucial role in cardioprotection under chronic hypoxia, thereby providing a potential therapeutic target for heart diseases associated with chronic Hypoxia. Expand
PPARα Inhibition Overcomes Tumor-Derived Exosomal Lipid-Induced Dendritic Cell Dysfunction
It is reported that fatty acid-carrying tumor-derived exosomes (TDEs) induce immune dysfunctional DCs to promote immune evasion and revealed that PPARα lies at the center of metabolic-immune regulation of DCs, suggesting a potential immunotherapeutic target. Expand
Antibiotic contaminants reduced the treatment efficiency of UV-C on Microcystis aeruginosa through hormesis.
Microcystin release in UV-C-treated cyanobacterial cells was further stimulated by the antibiotic mixture through the upregulation of mcyH and four ATP-binding cassette transport proteins and the interference effects of antibiotic contaminants should be fully considered whenUV-C is applied to control cyanob bacterial bloom in antibiotic-polluted environments. Expand
Hsp90B enhances MAST1-mediated cisplatin resistance by protecting MAST1 from proteosomal degradation.
- C. Pan, J. Chun, +14 authors Sumin Kang
- Chemistry, Medicine
- The Journal of clinical investigation
- 1 October 2019
This study not only uncovers the regulatory mechanism of MAST1 in tumors but also suggests a promising combinatorial therapy to overcome cisplatin resistance in human cancers. Expand
Mechanisms for the stimulatory effects of a five-component mixture of antibiotics in Microcystis aeruginosa at transcriptomic and proteomic levels.
Altering in the transcriptome of M. aeruginosa suggested the excitation of both photosynthesis and carbon metabolism, increasing energy generation in response to oxidative stress induced by low-dose antibiotics, and thus contributing to the significant (p < 0.05) increase in growth rate, Fv/Fm, and cell density. Expand
c-Jun promotes the survival of H9c2 cells under hypoxia via PTEN/Akt signaling pathway
- Fan Wu, F. Gao, Siyi He, Yunhan Jiang, Guiping Luo, Yingbin Xiao
- Biology, Medicine
- Journal of Physiology and Biochemistry
- 3 August 2019
It is demonstrated that the expression of c-Jun was induced by hypoxia in H9c2 cells and it was revealed that the knockdown ofc-Jun inhibited the PTEN/Akt signaling pathway under Hypoxia. Expand
Hsp 90 B enhances MAST 1-mediated cisplatin resistance by protecting MAST 1 from proteosomal degradation
Microtubule-associated serine/threonine kinase 1 (MAST1) is a central driver of cisplatin resistance in human cancers. However, the molecular mechanism regulating MAST1 levels in cisplatin-resistant… Expand
Antibiotics promoted the recovery of Microcystis aeruginosa after UV-B radiation at cellular and proteomic levels.
- Yunhan Jiang, Yuanfang Liu, J. Zhang, B. Gao
- Chemistry, Medicine
- Ecotoxicology and environmental safety
- 16 December 2019
The hypothesis that antibiotics accelerated the recovery of M. aeruginosa from UV-B induced damage was verified and a safe threshold of 20 ng/L was suggested for mixed antibiotics in order to eliminate the stimulatory effects of antibiotics on bloom-forming cyanobacteria. Expand
In vitro and ex vivo evaluation of tumor-derived exosome-induced dendritic cell dysfunction in mouse
A step-by-step protocol for TDE isolation and evaluation of TDEs on DCs both in vitro and ex vivo with high repeatability is described, useful for the interrogating TDE-DC interactions and identification of novel immune regulators. Expand
NNAL, a major metabolite of tobacco-specific carcinogen NNK, promotes lung cancer progression through deactivating LKB1 in an isomer-dependent manner
The results reveal, for the first time, that NNAL may promote lung cancer progression through LKB1 deactivation in an isomer-dependent manner. Expand