Yung-Chi Chang

Victor Nizet10
Ajit Varki8
10Victor Nizet
8Ajit Varki
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Human neutrophil Siglec-9 is a lectin that recognizes sialic acids (Sias) via an amino-terminal V-set Ig domain and possesses tyrosine-based inhibitory motifs in its cytoplasmic tail. We hypothesized that Siglec-9 recognizes host Sias as "self," including in cis interactions with Sias on the neutrophil's own surface, thereby dampening unwanted neutrophil(More)
A complete, low cost baseline JPEG encoder soft IP and its chip implementation are presented in this paper. It features user-defined, run-time re-configurable quantization tables, highly modularized and fully pipelined architecture. A prototype, synthesized with COMPASS cell library, has been implemented in TSMC 0.6-um single-poly, triple-metal process. It(More)
Group B Streptococcus (GBS) is a leading cause of invasive bacterial infections in human newborns. A key GBS virulence factor is its capsular polysaccharide (CPS), displaying terminal sialic acid (Sia) residues which block deposition and activation of complement on the bacterial surface. We recently demonstrated that GBS Sia can bind human CD33-related(More)
A cost-effective hardware architecture of integer, half, and quaner-pel motion estimation for MPEG-4 Advanced Simple Profile is proposed in this paper. Three-step hierarchy scheme is employed to cope with different pixel accuracy. For integer-pel estimation, the proposed computation-controllable algorithm makes it easy to be integrated into the coding(More)
Cell surface expression of sialic acid has been reported to decrease during immune cell activation, but the significance and regulation of this phenomenon are still being investigated. The major human bacterial pathogen Streptococcus pneumoniae causes pneumonia, sepsis and meningitis, often accompanied by strong inflammatory responses. S. pneumoniae(More)
Group B Streptococcus (GBS) is a common agent of bacterial sepsis and meningitis in newborns. The GBS surface capsule contains sialic acids (Sia) that engage Sia-binding immunoglobulin-like lectins (Siglecs) on leukocytes. Here we use mice lacking Siglec-E, an inhibitory Siglec of myelomonocytic cells, to study the significance of GBS Siglec engagement(More)