Learn More
Little is known about the potential ecotoxicity of engineered nanoparticles (NPs) to aquatic organisms. To carefully address this issue, we conducted a comprehensive toxicity assessment, including modified acute (72h) and chronic (21d) toxicity tests as well as nTiO(2) accumulation analysis using Daphnia magna as a model organism. We found that nTiO(2)(More)
With extensive use of metal oxide nanoparticles (NPs) in a variety of applications comes a higher potential of release into aquatic environments. NPs tend to form much larger aggregates in water, which are expected to settle down to the bottom of the water column and possibly get mixed with the sediments. However, little is known about the environmental(More)
As common engineered nanomaterials, TiO(2) nanoparticles (nTiO(2)) are usually perceived as non-toxic, and have already been widely used in many products and applications. Such a perception might have been shaped by some short-term studies that revealed no/low toxicity of nTiO(2) to cells and eco-relevant organisms. However, given the ultimate release of(More)
The DNA origami method, in which long, single-stranded DNA segments are folded into shapes by short staple segments, was used to create nucleic acid probe tiles that are molecular analogs of macroscopic DNA chips. One hundred trillion probe tiles were fabricated in one step and bear pairs of 20-nucleotide-long single-stranded DNA segments that act as probe(More)
Safe and effective vaccines offer the best intervention for disease control. One strategy to maximize vaccine immunogenicity without compromising safety is to rationally design molecular complexes that mimic the natural structure of immunogenic microbes but without the disease-causing components. Here we use highly programmable DNA nanostructures as(More)
Selection of genes that are differentially expressed and critical to a particular biological process has been a major challenge in post-array analysis. Recent development in bioinformatics has made various data sources available such as mRNA and miRNA expression profiles, biological pathway and gene annotation, etc. Efficient and effective integration of(More)
As an emerging model for toxicological studies, zebrafish has been explored for nanotoxicity assessment. In addition to endpoint examination of embryo/fish mortality and/or developmental disorders, molecular analyses of differential gene expression have also been employed to evaluate toxic effects associated with the exposure to nanomaterials. Here, we(More)
Despite wide applications of high-throughput biotechnologies in cancer research, many biomarkers discovered by exploring large-scale omics data do not provide satisfactory performance when used to predict cancer treatment outcomes. This problem is partly due to the overlooking of functional implications of molecular markers. Here, we present a novel(More)
Gene selection aims at detecting biologically relevant genes to assist biologists' research. The cDNA Microarray data used in gene selection is usually "wide". With more than ten thousand genes, but only less than a hundred of samples, many biologically irrelevant genes can gain their statistical relevance by sheer randomness. Moreover, even for genes that(More)
For heterogeneous multi-core SoCs, the increasing demand of the memory capacity and bandwidth becomes a critical design challenge. In this paper, an on-demand memory sub-system is presented to efficiently control the memory access and memory resource allocation using adaptively allocated cache memory. The proposed adaptively allocated cache memory can(More)