Yunchuan Delores Mo

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Site-directed mutagenesis, electron microscopy, and X-ray crystallography were used to probe the structural basis of annexin IV-induced membrane aggregation and the inhibition of this property by protein kinase C phosphorylation. Site-directed mutants that either mimic (Thr6Asp, T6D) or prevent (Thr6Ala, T6A) phosphorylation of threonine 6 were produced for(More)
BACKGROUND Annexin V, an abundant anticoagulant protein, has been proposed to exert its effects by self-assembling into highly ordered arrays on phospholipid membranes to form a protective anti-thrombotic shield at the cell surface. The protein exhibits very high-affinity calcium-dependent interactions with acidic phospholipid membranes, as well as specific(More)
Annexin V belongs to a family of eukaryotic calcium-dependent membrane-binding proteins. The calcium-binding sites at the annexin-membrane interface have been investigated in some detail; however, little is known about the functional roles of highly conserved interfacial residues that do not coordinate calcium themselves. In the present study, the(More)
Background. Serous tubal intraepithelial carcinoma (STIC) is a precursor lesion for high-grade pelvic serous carcinoma. The incidence of STIC is estimated to occur in 0.6% to 6% of women who are BRCA positive or have a strong family history of breast or ovarian cancer. Case. A 56-year-old woman underwent robotic-assisted sacrocolpopexy, rectocele repair,(More)
A novel method has been developed for the synthesis of thioglycolic acid (TGA)-capped CdSe quantum dots (QDs) in an aqueous medium when selenium dioxide worked as a selenium source and sodium borohydride acted as a reductant. The interaction between CdSe QDs and pepsin was investigated by fluorescence spectroscopy. It was proved that the fluorescence(More)
A procedure combining direct methods and solvent flattening to break the phase ambiguity intrinsic to the single isomorphous replacement (SIR) technique has been tested with the experimental SIR data of the known protein RNase Sa at 2.5 A resolution. The use of direct methods provided better initial phases for the solvent-flattening procedure, while the(More)
467 Background: Over the past decade, genitourinary pathologists have increasingly recognized an oncocytic variant of papillary renal cell carcinoma (PRC) that can complicate classification as Type 1 or Type 2 PRC. The International Society of Urological Pathology recently proposed reclassifying oncocytic papillary renal cell carcinoma (OPRC) as a separate(More)
Awoman in her 40s presented with progressive dyspnea and inability to lie flat. Two years prior to presentation, she had noticed a tender, firm thyroidenlargementassociatedwith rapidweightgain. She was hypothyroid with a thyroid-stimulating hormone level of 15.42mIU/Landa free thyroxine levelof0.95ng/dL. (Toconvert free thyroxine topicomolesper(More)
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