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Inducible expression of keratinocyte growth factor (KGF) in mice inhibits lung epithelial cell death induced by hyperoxia
  • P. Ray, Y. Devaux, +6 authors A. Ray
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 5 May 2003
TLDR
This work reports the development of a stringently regulated, tetracycline-inducible, lung-specific transgenic system that allows regulated expression of KGF in the lung without causing developmental abnormalities from leaky KGF expression and protects the lung epithelium but not the endothelium from cell death. Expand
Activated Akt Protects the Lung from Oxidant-Induced Injury and Delays Death of Mice
TLDR
It is shown that a constitutively active form of Akt introduced intratracheally into the lungs of mice by adenovirus gene transfer techniques protects mice from hyperoxic pulmonary damage and delays death of mice. Expand
Overexpression of a dominant-negative mutant of SIRT1 in mouse heart causes cardiomyocyte apoptosis and early-onset heart failure
TLDR
The results indicate that dominant negative form of SIRT1 (SIRT1H363Y) overexpression in mouse hearts causes cardiomyocyte apoptosis and early-onset heart failure, suggesting a critical role of Sirt1 in preserving normal cardiac development during the early postnatal period. Expand
Effect of telomerase inhibition on preclinical models of malignant rhabdoid tumor.
TLDR
The activity of imetelstat as a single agent suggests that further studies of telomerase inhibitors in combination with other agents may be warranted, and the effect of the telomere length, DNA damage response, and cell proliferation were assessed. Expand
p21-activated Protein Kinase 4 (PAK4) Interacts with the Keratinocyte Growth Factor Receptor and Participates in Keratinocyte Growth Factor-mediated Inhibition of Oxidant-induced Cell Death*
TLDR
The data demonstrate that PAK4 is an important mediator of the anti-apoptotic effects of KGF on epithelial cells, and the cytoplasmic domain of KGFR interacts with p21-activated protein kinase (PAK) 4, which is a new member of the PAK family. Expand
Endothelium-specific SIRT1 overexpression inhibits hyperglycemia-induced upregulation of vascular cell senescence
TLDR
Findings suggest that SIRT1-mediated inhibition of hyperglycemia-induced vascular cell senescence is mediated at least partly through the reduction of oxidative stress. Expand
p 53 NEGATIVELY REGULATES RGS 13 EXPRESSION IN IMMUNE CELLS
Shoko Iwaki, Yunbiao Lu, Zhihui Xie, and Kirk M. Druey* Molecular Signal Transduction Section, Laboratory of Allergic Diseases, NIAID/NIH, Bethesda, MD 20892 Running head: p53 suppresses RGS13Expand
p53 Negatively Regulates RGS13 Protein Expression in Immune Cells*
TLDR
Two p53 response elements (REs) are investigated and found that a 1000-bp DNA fragment upstream of the ATG translation start site (TSS) had promoter activity in reporter gene assays, and deletion or mutation of a p53-binding motif nearest the TSS abolished promoter activity. Expand