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MicroRNA-125b Induces Metastasis by Targeting STARD13 in MCF-7 and MDA-MB-231 Breast Cancer Cells
New insights are provided into the function of miR-125b during the metastasis of breast cancer cells and the role of miDLC2 was suggested in pro-metastasis by targeting STARD13. Expand
Isolation and structural characterization of a novel polysaccharide prepared from Arca subcrenata Lischke.
Preliminary in vitro tests revealed that ASLP can stimulate mouse spleen lymphocyte proliferation and its branches are extremely important for its immunological activity. Expand
Effects of SMYD3 over-expression on cell cycle acceleration and cell proliferation in MDA-MB-231 human breast cancer cells
It is shown here that down-regulation of SMYD3 could induce G1-phase cell cycle arrest, indicating the potent induction of apoptosis bySMYD3 knockdown and the development of strategies that may inhibit the progression of cell cycle in breast cancer cells. Expand
Cloning, expression, and characterization of a novel diketoreductase from Acinetobacter baylyi.
A novel enzyme designated as diketoreductase (DKR) that was able to reduce two carbonyl groups in a diketo ester to corresponding dihydroxy ester with excellent stereoselectivity could be utilized in the synthesis of valuable chiral drug intermediates, such as Lipitor. Expand
Immunological features and the ability of inhibitory effects on enzymatic activity of an epitope vaccine composed of cholera toxin B subunit and B cell epitope from Helicobacter pylori urease A
Epitope vaccine based on urease of Helicobacter pylori is a promising option for prophylactic and therapeutic vaccination against H. pylori infection. In this study, we constructed an epitope vaccineExpand
Ursolic acid induces HL60 monocytic differentiation and upregulates C/EBP&bgr; expression by ERK pathway activation
Results reported here show that UA can promote the monocytic differentiation of HL60 cells and increase the expression of CCAAT/enhancer-binding protein &bgr; by activating the ERK pathway, suggesting that UA could be a potential candidate as a differentiation-inducing agent for the therapeutic treatment of leukemia. Expand
A Bacterial Enzyme Catalyzing Double Reduction of a β,δ-Diketo Ester with Unprecedented Stereoselectivity
Various ketoreductases exclusively participate in all common biological events, and they are a class of important biocatalysts for the production of chiral alcohols. While many types of ketoreductaseExpand
Separation of structurally similar nocathiacin analogues by reversed phase chromatography.
A simple and effective chromatographic method to separate and purify nocathiacin acid from its structural analogue nocATHiacin I was developed and offers a new methodology for the separation of structurally closely related secondary metabolites. Expand
Catalytic Effects of Different Heparin Analogs on the Hydrolysis of Auramine O
It is demonstrated that the length of polysaccharide chain, the N- or O-sulfo groups are critical to the hydrolysis of 4,4′-(imidocarbonyl)-bis(N,N-dimethy-laniline) monohydrochloride in addition to pH and ionic strength, which provides new insights into the catalytic phenomenon ofpolysaccharides. Expand