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Anti-inflammatory effects of β-sitosterol-β-D-glucoside from Trachelospermum jasminoides (Apocynaceae) in lipopolysaccharide-stimulated RAW 264.7 murine macrophages
β-sitosterol-β-D-glucoside (1) was found to reduce nitric oxide (NO) production from LPS-induced RAW 264.7 cells the most and may be a useful candidate for the development of new drugs to treat endotoxemia and inflammation accompanied by the overproduction of NO. Expand
Neuroprotective effects of constituents of Eragrostis ferruginea against Aβ-induced toxicity in PC12 cells
Five known compounds and a new flavonoid were isolated from the aerial parts of Eragrostis ferruginea and demonstrated moderate neuroprotective effects against amyloid beta peptide using PC12 cells, a major cause of the pathology of Alzheimer’s disease. Expand
Antiinflammatory Effects of Functionally Active Compounds Isolated from Aged Black Garlic
The results suggested that compound AGE‐1 may have significant effects on inflammatory factors and could potentially be used as an antiinflammatory therapeutic agent. Expand
Anti-melanogenic effects of resveratryl triglycolate, a novel hybrid compound derived by esterification of resveratrol with glycolic acid
RTG can attenuate cellular melanin synthesis effectively through the suppression of MITF-dependent expression of melanogenic enzymes and the inhibition of catalytic activity of TYR enzyme, suggesting potential for use as a cosmeceutical ingredient for skin whitening. Expand
Inhibition of β-site amyloid precursor protein cleaving enzyme 1 and cholinesterases by pterosins via a specific structure−activity relationship with a strong BBB permeability
Pterosin derivatives extracted from bracken fern block the activity of three enzymes associated with Alzheimer’s disease in a concentration-dependent manner and suggested that several pterosins are potential scaffolds for multitarget-directed ligands (MTDLs) for AD therapeutics. Expand
Glycopentanolones A-D, four new geranylated quinolone alkaloids from Glycosmis pentaphylla.
Four new geranylated 2-quinolone alkaloids, named glycopentanolones A-D (1-4), and 12 known metabolites (5-16) were isolated from the ethanolic extract from the stems of G. pentaphylla using bioassay-guided fractionation. Expand
Two new furostanol glycosides from the fruits of Tribulus terrestris
Abstract Two new furostanol glycosides, named terrestrinones A1/A2 (1a/1b), were isolated from the fruits of Tribulus terrestris L. together with four known compounds, and their structures wereExpand
Phenolic Amides from the Fruits of Tribulus terrestris and Their Inhibitory Effects on the Production of Nitric Oxide
Phytochemical studies of this plant have yielded several steroidal saponins, flavonoids, phenolic amides, and alkaloids, which have applications in medicines and food supplements and in cardiovascular diseases. Expand
Ohioensins F and G: protein tyrosine phosphatase 1B inhibitory benzonaphthoxanthenones from the Antarctic moss Polytrichastrum alpinum.
Kinetic analysis of PTP1B inhibition by ohioensin F (1) suggested that benzonaphthoxanthenones inhibited PTP2B activity in a non-competitive manner, and showed potent inhibitory activity against therapeutically targeted protein tyrosine phosphatase 1B. Expand
Phenolic compounds from Pueraria lobata protect PC12 cells against Aβ-induced toxicity
Bioassay-guided fractionation of the EtOAc-soluble extract of Pueraria lobata based on the inhibition of Aβ-induced toxicity in PC12 cells resulted in the isolation of four known active compounds,Expand