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Real-time cooperative editing systems allow multiple users to view and edit the same text/graphic/image/multimedia document at the same time for multiple sites connected by communication networks. Consistency maintenance is one of the most significant challenges in designing and implementing real-time cooperative editing systems. In this article, a(More)
The cellular response to unfolded and misfolded proteins in the mitochondrial matrix is poorly understood. Here, we report on a genome-wide RNAi-based screen for genes that signal the mitochondrial unfolded protein response (UPR(mt)) in C. elegans. Unfolded protein stress in the mitochondria correlates with complex formation between a homeodomain-containing(More)
Genetic analyses previously implicated the matrix-localized protease ClpP in signaling the stress of protein misfolding in the mitochondrial matrix to activate nuclear-encoded mitochondrial chaperone genes in C. elegans (UPR(mt)). Here, we report that haf-1, a gene encoding a mitochondria-localized ATP-binding cassette protein, is required for signaling(More)
In scientific cloud workflows, large amounts of application data need to be stored in distributed data centres. To effectively store these data, a data manager must intelligently select data centres in which these data will reside. This is, however, not the case for data which must have a fixed location. When one task needs several datasets located in(More)
Perturbation of the protein-folding environment in the mitochondrial matrix selectively upregulates the expression of nuclear genes encoding mitochondrial chaperones. To identify components of the signal transduction pathway(s) mediating this mitochondrial unfolded protein response (UPR(mt)), we first isolated a temperature-sensitive mutation (zc32) that(More)
The full scale of human miRNome in specific cell or tissue, especially in cancers, remains to be determined. An in-depth analysis of miRNomes in human normal liver, hepatitis liver, and hepatocellular carcinoma (HCC) was carried out in this study. We found nine miRNAs accounted for ∼88.2% of the miRNome in human liver. The third most highly expressed(More)
The ability to accurately perceive the direction and speed of moving objects declines during normal aging. This is likely due to functional degradation of cortical neurons. Most neurons in the primate middle temporal area (MT) are direction-selective and their activity is closely linked to the perception of coherent motion. We investigated the mechanisms(More)
At present, workflow management systems have not sufficiently dealt with the issues of time, involving time modelling at build-time and time management at run-time. They are lack of the ability to support the checking of temporal constraints at run-time. Although some approaches have been devised to tackle this problem, they are limited to a single workflow(More)
A cloud workflow system is a type of platform service which facilitates the automation of distributed applications based on the novel cloud infrastructure. One of the most important aspects which differentiate a cloud workflow system from its other counterparts is the market-oriented business model. This is a significant innovation which brings many(More)
A workflow specification is a formal description of business processes in the real world. Its correctness is critical to the workflow execution and hence the realisation of business objectives. In addition to structural and temporal constraints, resource constraints are also implied in workflow specifications. Therefore, they should be analysed to ensure(More)