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Pulsatile flow was studied in physiologically realistic models of a normal and a moderately stenosed (30% diameter reduction) human carotid bifurcation. Time-resolved velocity measurements were made using magnetic resonance imaging, from which wall shear stress (WSS) vectors were calculated. Velocity measurements in the inflow and outflow regions were also(More)
Icariin (ICA) has neuroprotection in oxygen-glucose deprivation (OGD) neurons by increasing Sirtuin1 (SIRT1). However, little is known about the role of ICA on stroke. SIRT1 is a class III histone deacetylase and activates peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) which stimulates mitochondrial activity. This study(More)
Individuals are thought to have their own distinctive scent, analogous to a signature or fingerprint. To test this idea, we collected axillary sweat, urine and saliva from 197 adults from a village in the Austrian Alps, taking five sweat samples per subject over 10 weeks using a novel skin sampling device. We analysed samples using stir bar sorptive(More)
BACKGROUND Abdominal aortic aneurysm (AAA) is a dilatation of the aortic wall, which can rupture, if left untreated. Previous work has shown that, maximum diameter is not a reliable determinant of AAA rupture. However, it is currently the most widely accepted indicator. Wall stress may be a better indicator and promising patient specific results from(More)
BACKGROUND Osteoporotic compression fractures (OVCFs) commonly occur in aged people, and as much as one-third of these fractures progress to chronic pain. Kyphoplasty (KP) is proved to be efficacious for pain relief and vertebral height restoration in chronic OVCFs, but there is still no data available about the clinical and radiographical outcomes compared(More)
Interest in histone deacetylase (HDAC)-based therapeutics as a potential treatment for stroke has grown dramatically. The neuroprotection of HDAC inhibition may involve multiple mechanisms, including modulation of transcription factor acetylation independent of histones. The transcription factor Nrf2 has been shown to be protective in stroke as a key(More)
STUDY DESIGN A comparative study of chronic painful osteoporotic vertebral compression fractures (OVCFs), which underwent kyphoplasty via unipedicular versus bipedicular approach. OBJECTIVE To assess the clinical and radiographical outcomes in treating chronic painful OVCFs compared by unipedicular and bipedicular kyphoplasty (KP). SUMMARY OF BACKGROUND(More)
The peroxisome proliferator activated receptor coactivator 1 alpha (PGC-1α) is a nuclear transcriptional coactivator that is widely expressed in the brain areas. Over-expression of PGC-1α can protect neuronal cells from oxidant-induced injury. The purpose of the current study is to investigate the role of PGC-1α in the oxygen (anoxia) deprivation (OGD)(More)
Motif is overrepresented pattern in biological sequence and Motif finding is an important problem in bioinformatics. Due to high computational complexity of motif finding, more and more computational capabilities are required as the rapid growth of available biological data, such as gene transcription data. Among many motif finding algorithms, Gibbs(More)
Ischemic stroke is a debilitating clinical disorder that affects millions of people, yet lacks effective neuroprotective treatments. Fish oil is known to exert beneficial effects against cerebral ischemia. However, the underlying protective mechanisms are not fully understood. The present study tests the hypothesis that omega-3 polyunsaturated fatty acids(More)