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Investigation of transcription factors (TFs) and their downstream regulated genes (targets) is a significant issue in post-genome era, which can provide a brand new vision for some vital biological process. However, information of TFs and their targets in mammalian is far from sufficient. Here, we developed an integrated TF platform (ITFP), which included(More)
Small-diameter blood vessel substitutes are urgently needed for patients requiring replacements of their coronary and below-the-knee vessels and for better arteriovenous dialysis shunts. Circulatory diseases, especially those arising from atherosclerosis, are the predominant cause of mortality and morbidity in the developed world. Current therapies include(More)
OBJECTIVE To investigate the effects of cryoprotectants on the expression of AQP7 in oocytes. DESIGN Experimental animal study. SETTING University-based research laboratory. ANIMAL(S) Adult female C57BL/6J mice. INTERVENTION(S) In metaphase II (MII) oocytes obtained from adult female C57BL/6J mice and from donations by fertile women, the mouse(More)
Tubulin is known to undergo unique post-translational modifications (PTMs), such as detyrosination and polyglutamylation, particularly in the unstructured carboxy-terminal tails (CTTs). However, more conventional PTMs of tubulin and their roles in the regulation of microtubule properties and functions remain poorly defined. Here, we report the comprehensive(More)
Sequential pattern mining is now widely used in various areas, such as the analysis of biological sequences, Web access patterns, customer purchase patterns and etc. In this paper, we propose a new definition for M-sequences. Also we present multiple supports: local support, total support, and distribution support for their related mining of local(More)
As a newly emerging network model, heterogeneous information networks (HINs) have received growing attention. Many data mining tasks have been explored in HINs, including clustering, classification, and similarity search. Similarity join is a fundamental operation required for many problems. It is attracting attention from various applications on network(More)
In contrast to the well-established chemistry of ketones (R2C=O), the reactivity of the elusive heavier congeners R2E=O (E=Si, Ge, Sn, Pb) is far less explored because of the high polarity of the E=O bonds and hence their tendency to oligomerize with no activation barrier. Very recently, great advances have been achieved in the synthesis of isolable(More)
The essence of computer applications is to store things in the real world into computer systems in the form of data, i.e., it is a process of producing data. Some data are the records related to culture and society, and others are the descriptions of phenomena of universe and life. The large scale of data is rapidly generated and stored in computer systems,(More)