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Cholera is still a significant public health issue in developing countries. The aetiological agent is Vibrio cholerae and only two serogroups, O1 and O139, are known to cause pandemic or epidemic cholera. In contrast, non-O1/non-O139 V. cholerae has only been reported to cause sporadic cholera-like illness and localised outbreaks. The aim of this study was(More)
—In this paper we present our research work in traffic sign detection and classification. Specifically we present a set of asymmetric Haar-like features that will be shown to be effective in reducing false alarm rates for traffic sign detection, and a robust multi-class traffic sign detection and classification system built based upon the stage-by-stage(More)
Web services promise to allow businesses to adapt rapidly to changes in the business environment, and the needs of different customers. The rapid introduction of new web services into a dynamic business environment can lead to undesirable interactions that negatively impact service quality and user satisfaction. In previous work, we have shown how to model(More)
Computational methodologies that couple the dynamical evolution of a set of replicated copies of a system of interest offer powerful and flexible approaches to characterize complex molecular processes. Such multiple copy algorithms (MCAs) can be used to enhance sampling, compute reversible work and free energies, as well as refine transition pathways.(More)
BACKGROUND The p38 mitogen-activated protein kinase (p38 MAPK) is an important intracellular signal transduction pathway involved in TGF-β1-induced epithelial-mesenchymal transition (EMT). Sema4C, a member of the semaphorin family, was found to be essential for the activation of p38 MAPK. However, the role of Sema4C in promoting TGF-β1-induced EMT is(More)
This paper presents a pedestrian model built collectively on a group of strong local convex shape descriptors. The pedestrian model captures the most important features of a pedestrian: head, body contour, arms, legs and crotch, and is robust to variances in appearances and partial occlusions. For an image set of 2571 pedestrians and 4369 car and background(More)
The peroxisome proliferator activated receptor coactivator 1 alpha (PGC-1alpha) is a nuclear transcriptional coactivator that is widely expressed in the brain areas. Over-expression of PGC-1alpha can protect neuronal cells from oxidant-induced injury. The purpose of the current study is to investigate the role of PGC-1alpha in the oxygen (anoxia)(More)
Resveratrol (3,4',5-trihydroxystilbene) is a naturally derived phytoalexin stilbene isolated from grapes and other plants, playing an important role in human health and is well known for its extensive bioactivities, such as antioxidation, anti-inflammatory, anticancer. In addition to resveratrol, scientists also pay attention to resveratrol oligomers,(More)
Doxorubicin (Dox) is an anthracycline antibiotic for cancer therapy with limited usage due to cardiotoxicity. Isorhamnetin is a nature antioxidant with obvious cardiac protective effect. The aim of this study is going to investigate the possible protective effect of isorhamnetin against Dox-induced cardiotoxicity and its underlying mechanisms. In an in vivo(More)