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The case-crossover design was introduced in epidemiology 15 years ago as a method for studying the effects of a risk factor on a health event using only cases. The idea is to compare a case's exposure immediately prior to or during the case-defining event with that same person's exposure at otherwise similar "reference" times. An alternative approach to the(More)
The prevalence of antibiotic-resistant bacteria in municipal wastewater treatment plants (WWTPs) is becoming a concern of public health. In order to acquire information on the emission of antibiotic-resistant bacteria from WWTP effluents into natural waters, both average antibiotic tolerance and concentrations of antibiotic-resistant bacteria in the(More)
BACKGROUND In neuroscience clinical research studies, much time and effort are devoted to deciding what data to collect and developing data collection forms and data management systems to capture the data. Many investigators receiving funding from National Institute of Neurological Disorders and Stroke (NINDS), the National Institutes of Health (NIH), are(More)
Repetitive or overuse disorders of the lumbar spine affect the lives of workers and athletes. We hypothesize that repetitive anterior lumbar flexion–extension under low or high load will result in significantly elevated pro-inflammatory cytokines expression several hours post-activity. High loads will exhibit significantly higher expression than low loads.(More)
BACKGROUND Cyclic load applied to various joints during occupational and sports activities is epidemiologically linked to higher risk of neuromuscular disorder development. HYPOTHESIS Passive cyclic loading of the knee will develop laxity and creep in the anterior cruciate ligament, and these may elicit a neuromuscular disorder in the quadriceps and(More)
Previous studies in narcolepsy, an autoimmune disorder affecting hypocretin (orexin) neurons and recently associated with H1N1 influenza, have demonstrated significant associations with five loci. Using a well-characterized Chinese cohort, we refined known associations in TRA@ and P2RY11-DNMT1 and identified new associations in the TCR beta (TRB@; rs9648789(More)
We show how to create a semantics-based, parameterized translator from model-based notations to SMV, using template semantics. Our translator takes as input a specification and a set of user-provided parameters that encode the specification's semantics; it produces an SMV model suitable for model checking. Using such a translator, we can model check a(More)
Aerogels, an extremely important aggregation state of various self-assembled nanoscale building blocks, have great potential in fields ranging from energy storage to thermal insulation. However, the porosity of aerogels makes them mechanically weak in most cases, and the chemical activity of the resulting aerogel needs consideration. Herein, chemically(More)
The American Heart Association aims to improve cardiovascular health by encouraging the general population to meet 7 cardiovascular health behaviors and factors. The atherogenic index of plasma (AIP) is an important index. Our aim is to evaluate the relationship between ideal cardiovascular health and the atherogenic index of plasma (AIP) in middle-aged(More)
With the rapid development of the smart grid, a large volume of smart meter data are collected in the form of time series, which is called load profiles. This paper investigates the load profile clustering of smart grid customers, which is significant for many applications. An adaptive weighted fuzzy clustering algorithm is proposed to cluster load(More)