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Supply chain management (SCM) is a strategic paradigm to coordinate cash, material, and information flows from raw material to customer. Supply chain simulation (SCS) is a strong and popular tool for designing, evaluating, and optimizing the structure of supply chains, and it requires an important task to estimate the effect of the planning to coordinate(More)
Many inference methods of queueing systems have been developed on the basis of Larson's QIE(queue inference engine) with the assumption of homogeneous Poisson arrivals. It inferred the queueing systems with starting and ending times of service. However, the arrival processes are becoming complex lately, so there are some limits to apply the method. Our(More)
Human neurodegenerative diseases such as Parkinson's disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS) and Alzheimer's disease (AD) are caused by a loss of neurons and glia in the brain or spinal cord. Neurons and glial cells have successfully been generated from stem cells such as embryonic stem cells (ESCs), mesenchymal stem(More)
BACKGROUND Midkine (MK), a member of the heparin-binding growth factor family, which includes MK and pleiotrophin, is known to possess neurotrophic and neuroprotective properties in the central nervous system. Previous studies have shown that MK is an effective neuroprotective agent in reducing retinal degeneration caused by excessive light and decreasing(More)
Alzheimer's disease (AD) is characterized by degeneration and loss of neurons and synapses throughout the brain, causing the progressive decline in cognitive function leading to dementia. No effective treatment is currently available. Nerve growth factor (NGF) therapy has been proposed as a potential treatment of preventing degeneration of basal forebrain(More)
advancement of computer technologies enables us to answer to " How to " questions as well. An efficient " Simulation Gptimization " technique is developed to solve system design problems which can not be expressed in explicit analytical or mathematical models. In particular, we explore a new paradigm called the " Reverse-Simulation optimization method'(More)
Simulating rare events in telecommunication networks such as estimation for cell loss probability in Asynchronous Transfer Mode (ATM) networks requires a major simulation effort due to the slight chance of buffer overflow. Importance Sampling (IS) is applied to accelerate the occurrence of rare events. Importance Sampling depends on a biasing scheme to make(More)
BACKGROUND/AIMS The purpose of this study was to evaluate the clinicopathologic characteristics of colon cancers detected at the SOK Sokpeynhan Internal Medical Network, a nationwide system of primary health care institutions. METHODS We analyzed 579 colon cancer patients diagnosed using colonoscopy at the SOK network from January 2011 through December(More)
BACKGROUNDS In the present study, we aimed to examine the anti-aging properties of human placental hydrolysate (HPE) and dieckol (DE) from Ecklonia cava against free radical scavenging, muscle hypertrophy-related follistatin mRNA expression, amelioration of cognition-related genes and proteins, inhibition of collagenase-regulating genes, and elastinase(More)