• Publications
  • Influence
Psoralidin, a coumestan analogue, as a novel potent estrogen receptor signaling molecule isolated from Psoralea corylifolia.
Psoralidin is able to mimic the binding interactions of E2, and thus, it could act as an ER agonist in the cellular environment, as shown by chromatin immunoprecipitation assay results. Expand
Angelica keiskei, an emerging medicinal herb with various bioactive constituents and biological activities
The crude extracts and pure constituents of A. keiskei were proven to inhibit tumor growth and ameliorate inflammation, obesity, diabetics, hypertension, and ulcer, and showed anti-thrombotic, anti-oxidative,Anti-hyperlipidemic, Anti-viral, and anti-bacterial activities. Expand
A new secoiridoid glycoside from the fruits of Cornus officinalis (Cornaceae)
Abstract A new secoiridoid glycoside, 7β-O-dimethyl butanedioate morroniside (1) was isolated from the fruits of Cornus officinalis (Cornaceae) along with the known compound, caffeoyltartaric acidExpand
Peroxynitrite-Scavenging Glycosides from the Stem Bark of Catalpa ovata.
Ten new glycosides were isolated from the stem bark of Catalpa ovata along with 19 known compounds, and 12 compounds showed potent activity, with IC50 values in the range 0.14-2.2 μM. Expand
A New 9,10-Dihydrophenanthrene and Cell Proliferative 3,4-δ-Dehydrotocopherols from Stemona tuberosa
3,4-δ-dehydrotocopherols, especially pure isomers 2 and 3 can be suggested as potential wound healing agents and none of them induced cancer cell proliferation. Expand
Inhibitory effects of Stemona tuberosa on lung inflammation in a subacute cigarette smoke-induced mouse model
It is observed that the lung tissues of mice treated with ST showed ameliorated epithelial hyperplasia of the bronchioles compared with those of mice exposed only to CS, indicating that Stemona tuberosa may represent a novel therapeutic herb for the treatment of lung diseases including COPD. Expand
Tuberostemonine N, an active compound isolated from Stemona tuberosa, suppresses cigarette smoke-induced sub-acute lung inflammation in mice.
Data suggest that tuberostemonine N exerts anti-inflammatory effects against airway inflammation, and T.N may be a novel therapeutic agent for lung diseases, such as COPD. Expand
Heat Shock Factor 1 Inducers from the Bark of Eucommia ulmoides as Cytoprotective Agents
Coniferaldehyde glucoside showed the most effective increase of HSF1 and induced successive expressions of HSP27 and HSP70 in a dose‐dependent manner without cellular cytotoxicity, suggesting a possible application as a HSP inducer to act as cytoprotective agent. Expand
Chalcones from Angelica keiskei: Evaluation of Their Heat Shock Protein Inducing Activities.
Five new chalcones, 4,2',4'-trihydroxy-3'-[(2E,5E)-7-methoxy-3,7-dimethyl-2,5-octadienyl]chalcone, were isolated from the aerial parts of Angelica keiskei Koidzumi together with eight known chalCones, 6-13, which seem to be a prospective HSP inducer. Expand